• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Antisense-RNA-mediated decreased synthesis of small, acid-soluble spore proteins leads to decreased resistance of clostridium perfringens spores to moist heat and UV radiation.反义RNA介导的小酸溶性芽孢蛋白合成减少导致产气荚膜梭菌芽孢对湿热和紫外线辐射的抗性降低。
Appl Environ Microbiol. 2007 Apr;73(7):2048-53. doi: 10.1128/AEM.02500-06. Epub 2007 Jan 26.
2
Role of small, acid-soluble spore proteins in the resistance of Clostridium perfringens spores to chemicals.小酸溶性芽孢蛋白在产气荚膜梭菌芽孢对化学物质抗性中的作用。
Int J Food Microbiol. 2008 Mar 20;122(3):333-5. doi: 10.1016/j.ijfoodmicro.2007.12.006. Epub 2007 Dec 23.
3
Roles of DacB and spm proteins in clostridium perfringens spore resistance to moist heat, chemicals, and UV radiation.DacB和spm蛋白在产气荚膜梭菌孢子对湿热、化学物质和紫外线辐射的抗性中的作用。
Appl Environ Microbiol. 2008 Jun;74(12):3730-8. doi: 10.1128/AEM.00169-08. Epub 2008 Apr 25.
4
Effect of a small, acid-soluble spore protein from Clostridium perfringens on the resistance properties of Bacillus subtilis spores.产气荚膜梭菌的一种小的酸溶性芽孢蛋白对枯草芽孢杆菌芽孢抗性特性的影响。
J Bacteriol. 2007 Nov;189(21):7927-31. doi: 10.1128/JB.01179-07. Epub 2007 Aug 31.
5
Investigating the role of small, acid-soluble spore proteins (SASPs) in the resistance of Clostridium perfringens spores to heat.研究小分子酸性可溶性芽孢蛋白（SASPs）在产气荚膜梭菌芽孢耐热性中的作用。
BMC Microbiol. 2006 Jun 8;6:50. doi: 10.1186/1471-2180-6-50.
6
Characterization of Clostridium perfringens spores that lack SpoVA proteins and dipicolinic acid.缺乏SpoVA蛋白和吡啶二羧酸的产气荚膜梭菌孢子的特性分析
J Bacteriol. 2008 Jul;190(13):4648-59. doi: 10.1128/JB.00325-08. Epub 2008 May 9.
7
Spores of Bacillus subtilis: their resistance to and killing by radiation, heat and chemicals.枯草芽孢杆菌的孢子：它们对辐射、热和化学物质的抗性及被其杀灭的情况。
J Appl Microbiol. 2006 Sep;101(3):514-25. doi: 10.1111/j.1365-2672.2005.02736.x.
8
Heat, hydrogen peroxide, and UV resistance of Bacillus subtilis spores with increased core water content and with or without major DNA-binding proteins.核心含水量增加且有或无主要DNA结合蛋白的枯草芽孢杆菌孢子的耐热性、耐过氧化氢性和耐紫外线性。
Appl Environ Microbiol. 1995 Oct;61(10):3633-8. doi: 10.1128/aem.61.10.3633-3638.1995.
9
Different small, acid-soluble proteins of the alpha/beta type have interchangeable roles in the heat and UV radiation resistance of Bacillus subtilis spores.不同的α/β型小酸溶性蛋白在枯草芽孢杆菌孢子的耐热性和抗紫外线辐射方面具有可互换的作用。
J Bacteriol. 1987 Aug;169(8):3633-7. doi: 10.1128/jb.169.8.3633-3637.1987.
10
Production of small, acid-soluble spore proteins in Clostridium perfringens nonfoodborne gastrointestinal disease isolates.产气荚膜梭菌非食源性胃肠道疾病分离株中小的、酸溶性孢子蛋白的产生。
Can J Microbiol. 2007 Apr;53(4):514-8. doi: 10.1139/W07-016.

引用本文的文献

1
The small acid-soluble proteins of Clostridioides difficile regulate sporulation in a SpoIVB2-dependent manner.艰难梭菌的小酸性可溶性蛋白以 SpoIVB2 依赖的方式调节孢子形成。
PLoS Pathog. 2024 Aug 30;20(8):e1012507. doi: 10.1371/journal.ppat.1012507. eCollection 2024 Aug.
2
Clostridial Myonecrosis: A Comprehensive Review of Toxin Pathophysiology and Management Strategies.梭菌性肌坏死：毒素病理生理学与管理策略的全面综述
Microorganisms. 2024 Jul 18;12(7):1464. doi: 10.3390/microorganisms12071464.
3
The small acid-soluble proteins of spore-forming organisms: similarities and differences in function.芽孢形成生物体的小酸溶性蛋白：功能上的异同。
Anaerobe. 2024 Jun;87:102844. doi: 10.1016/j.anaerobe.2024.102844. Epub 2024 Apr 4.
4
The small acid-soluble proteins of regulate sporulation in a SpoIVB2-dependent manner.的小酸溶性蛋白以依赖SpoIVB2的方式调节孢子形成。
bioRxiv. 2024 Jun 25:2023.05.17.541253. doi: 10.1101/2023.05.17.541253.
5
New Thoughts on an Old Topic: Secrets of Bacterial Spore Resistance Slowly Being Revealed.旧话题的新思考：细菌孢子抗性的秘密正在逐渐被揭示。
Microbiol Mol Biol Rev. 2023 Jun 28;87(2):e0008022. doi: 10.1128/mmbr.00080-22. Epub 2023 Mar 16.
6
Inactivation of C1 Spores by the Combination of Mild Heat and Lactic Acid.温和加热与乳酸联合作用对C1芽孢的灭活
Foods. 2022 Nov 23;11(23):3771. doi: 10.3390/foods11233771.
7
Small Prokaryotic DNA-Binding Proteins Protect Genome Integrity throughout the Life Cycle.小型原核 DNA 结合蛋白在整个生命周期中保护基因组完整性。
Int J Mol Sci. 2022 Apr 4;23(7):4008. doi: 10.3390/ijms23074008.
8
Insights into the Structure and Protein Composition of Spores Formed at Different Temperatures.对不同温度下形成的孢子的结构和蛋白质组成的见解。
Int J Mol Sci. 2022 Jan 4;23(1):550. doi: 10.3390/ijms23010550.
9
The small acid-soluble proteins of Clostridioides difficile are important for UV resistance and serve as a check point for sporulation.艰难梭菌的小酸性可溶性蛋白对于抗紫外线辐射很重要，并作为孢子形成的检查点。
PLoS Pathog. 2021 Sep 8;17(9):e1009516. doi: 10.1371/journal.ppat.1009516. eCollection 2021 Sep.
10
Pathogenicity and virulence of .的致病性和毒力。
Virulence. 2021 Dec;12(1):723-753. doi: 10.1080/21505594.2021.1886777.

本文引用的文献

1
Spores of Bacillus subtilis: their resistance to and killing by radiation, heat and chemicals.枯草芽孢杆菌的孢子：它们对辐射、热和化学物质的抗性及被其杀灭的情况。
J Appl Microbiol. 2006 Sep;101(3):514-25. doi: 10.1111/j.1365-2672.2005.02736.x.
2
Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens.产毒细菌病原体产气荚膜梭菌菌株中的基因组变异偏倚
Genome Res. 2006 Aug;16(8):1031-40. doi: 10.1101/gr.5238106. Epub 2006 Jul 6.
3
Investigating the role of small, acid-soluble spore proteins (SASPs) in the resistance of Clostridium perfringens spores to heat.研究小分子酸性可溶性芽孢蛋白（SASPs）在产气荚膜梭菌芽孢耐热性中的作用。
BMC Microbiol. 2006 Jun 8;6:50. doi: 10.1186/1471-2180-6-50.
4
The forespore line of gene expression in Bacillus subtilis.枯草芽孢杆菌中的芽孢前体基因表达谱系。
J Mol Biol. 2006 Apr 21;358(1):16-37. doi: 10.1016/j.jmb.2006.01.059. Epub 2006 Feb 8.
5
Antisense RNA downregulation of coenzyme A transferase combined with alcohol-aldehyde dehydrogenase overexpression leads to predominantly alcohologenic Clostridium acetobutylicum fermentations.辅酶A转移酶的反义RNA下调与醇醛脱氢酶过表达相结合，导致主要产生酒精的丙酮丁醇梭菌发酵。
J Bacteriol. 2003 Jun;185(12):3644-53. doi: 10.1128/JB.185.12.3644-3653.2003.
6
Design of antisense RNA constructs for downregulation of the acetone formation pathway of Clostridium acetobutylicum.用于下调丙酮丁醇梭菌丙酮生成途径的反义RNA构建体的设计
J Bacteriol. 2003 Mar;185(6):1923-34. doi: 10.1128/JB.185.6.1923-1934.2003.
7
Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater.产气荚膜梭菌（一种厌氧性食肉菌）的全基因组序列
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):996-1001. doi: 10.1073/pnas.022493799. Epub 2002 Jan 15.
8
Resistance of spores of Bacillus species to ultraviolet light.芽孢杆菌属孢子对紫外线的抗性。
Environ Mol Mutagen. 2001;38(2-3):97-104. doi: 10.1002/em.1058.
9
Improvement and optimization of two engineered phage resistance mechanisms in Lactococcus lactis.乳酸乳球菌中两种工程化噬菌体抗性机制的改进与优化。
Appl Environ Microbiol. 2001 Feb;67(2):608-16. doi: 10.1128/AEM.67.2.608-616.2001.
10
Comparative experiments to examine the effects of heating on vegetative cells and spores of Clostridium perfringens isolates carrying plasmid genes versus chromosomal enterotoxin genes.比较实验，以研究加热对携带质粒基因与染色体肠毒素基因的产气荚膜梭菌分离株的营养细胞和芽孢的影响。
Appl Environ Microbiol. 2000 Aug;66(8):3234-40. doi: 10.1128/AEM.66.8.3234-3240.2000.

反义RNA介导的小酸溶性芽孢蛋白合成减少导致产气荚膜梭菌芽孢对湿热和紫外线辐射的抗性降低。

Antisense-RNA-mediated decreased synthesis of small, acid-soluble spore proteins leads to decreased resistance of clostridium perfringens spores to moist heat and UV radiation.

作者信息

Raju Deepa, Setlow Peter, Sarker Mahfuzur R

机构信息

Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331, USA.

出版信息

Appl Environ Microbiol. 2007 Apr;73(7):2048-53. doi: 10.1128/AEM.02500-06. Epub 2007 Jan 26.

DOI:10.1128/AEM.02500-06
PMID:17259355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1855649/
Abstract

Previous work has suggested that a group of alpha/beta-type small, acid-soluble spore proteins (SASP) is involved in the resistance of Clostridium perfringens spores to moist heat. However, this suggestion is based on the analysis of C. perfringens spores lacking only one of the three genes encoding alpha/beta-type SASP in this organism. We have now used antisense RNA to decrease levels of alpha/beta-type SASP in C. perfringens spores by approximately 90%. These spores had significantly reduced resistance to both moist heat and UV radiation but not to dry heat. These results clearly demonstrate the important role of alpha/beta-type SASP in the resistance of C. perfringens spores.

摘要

先前的研究表明，一组α/β型小的、酸溶性芽孢蛋白（SASP）参与了产气荚膜梭菌芽孢对湿热的抗性。然而，这一推测是基于对仅缺失该生物体中编码α/β型SASP的三个基因之一的产气荚膜梭菌芽孢的分析。我们现在利用反义RNA将产气荚膜梭菌芽孢中α/β型SASP的水平降低了约90%。这些芽孢对湿热和紫外线辐射的抗性显著降低，但对干热的抗性未降低。这些结果清楚地证明了α/β型SASP在产气荚膜梭菌芽孢抗性中的重要作用。