Lin Julie, Hu Frank B, Curhan Gary
Renal Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Diabetes Care. 2007 Feb;30(2):239-44. doi: 10.2337/dc06-1296.
Inflammation is associated with both chronic kidney dysfunction and type 2 diabetes. Adiponectin, a novel circulating anti-inflammatory protein made by adipocytes, has been reported to be lower in diabetic than nondiabetic subjects. In contrast, serum levels of adiponectin are elevated in end-stage renal disease. We sought to investigate the relation between adiponectin and mild to moderate renal dysfunction in men with type 2 diabetes.
Multivariate logistic regression was used to evaluate the relation between serum adiponectin concentrations and the presence of renal dysfunction (estimated glomerular filtration rate [eGFR] <60 ml/min per 1.73 m(2) by the four-variable Modification of Diet in Renal Disease equation) in participants with type 2 diabetes in the Health Professionals' Follow-Up Study. A total of 733 men were included in this cross-sectional analysis.
Adiponectin was positively correlated with age (Spearman coefficient, r = 0.19, P < 0.001) and negatively correlated with weight (Spearman coefficient, r = -0.18, P < 0.001). Those with adiponectin in the second quartile or higher (>10 microg/ml) compared with those in the first quartile had a reduced odds for renal dysfunction (multivariate odds ratio 0.48 [95% CI 0.28-0.81]). These results were unchanged when serum lipids were included in the multivariate model.
We conclude that a higher serum adiponectin concentration is associated with reduced odds of moderate renal dysfunction in men with type 2 diabetes.
炎症与慢性肾功能不全和2型糖尿病均相关。脂联素是一种由脂肪细胞分泌的新型循环抗炎蛋白，据报道，糖尿病患者体内的脂联素水平低于非糖尿病患者。相反，终末期肾病患者的血清脂联素水平升高。我们试图研究2型糖尿病男性患者中脂联素与轻至中度肾功能不全之间的关系。
在健康专业人员随访研究中，采用多因素logistic回归分析2型糖尿病参与者血清脂联素浓度与肾功能不全（根据肾脏病饮食改良方程的四变量公式估算肾小球滤过率[eGFR]<60 ml/min/1.73 m²）之间的关系。本横断面分析共纳入733名男性。
脂联素与年龄呈正相关（Spearman系数，r = 0.19，P < 0.001），与体重呈负相关（Spearman系数，r = -0.18，P < 0.001）。与第一四分位数的参与者相比，脂联素处于第二四分位数及以上（>10 μg/ml）的参与者肾功能不全的几率降低（多因素比值比0.48 [95%CI 0.28 - 0.81]）。当多因素模型中纳入血脂时，这些结果不变。
我们得出结论，较高的血清脂联素浓度与2型糖尿病男性患者中度肾功能不全几率降低相关。
