从鹅不食草中分离得到的抗菌百里香酚衍生物。
Antibacterial thymol derivatives isolated from Centipeda minima.
作者信息
Liang Hengxing, Bao Fukai, Dong Xiaoping, Tan Rui, Zhang Caijun, Lu Qing, Cheng Yongxian
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
出版信息
Molecules. 2007 Jan 27;12(8):1606-13. doi: 10.3390/12081606.
Abstract
Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-beta-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-hydroxy-9,10-diisobutyryloxythymol (7), were isolated from Centipeda minima. Their structures were identified by means of spectroscopic analyses. Interestingly, compound 2 is not an extraction artifact according to a close HPLC examination of material after extraction by analytical MeOH at ambient temperature. The antibacterial activities of compounds 1-7 were evaluated against eight microbial strains by the agar dilution method.
摘要
从最小石胡荽中分离出两种新的单萜类化合物，8,10 - 二羟基 - 9(2) - 甲基丁酰氧基百里香酚（1）和10 - 羟基 - 8,9 - 二氧亚异丙基百里香酚（2），以及五种已知的百里香酚衍生物：8,9,10 - 三羟基百里香酚（3）、百里香酚 - β - 葡萄糖苷（4）、9 - 羟基百里香酚（5）、8,10 - 二羟基 - 9 - 异丁酰氧基百里香酚（6）和8 - 羟基 - 9,10 - 二异丁酰氧基百里香酚（7）。通过光谱分析确定了它们的结构。有趣地是，根据在室温下用分析纯甲醇萃取后对物质进行的仔细高效液相色谱检查，化合物2不是萃取假象。采用琼脂稀释法评估了化合物1 - 7对八种微生物菌株的抗菌活性。
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