茶饮与基底细胞癌和鳞状细胞皮肤癌：一项病例对照研究的结果
Tea consumption and basal cell and squamous cell skin cancer: results of a case-control study.
作者信息
Rees Judy R, Stukel Therese A, Perry Ann E, Zens Michael S, Spencer Steven K, Karagas Margaret R
机构信息
Department of Community and Family Medicine (Section of Biostatistics and Epidemiology), Dartmouth Medical School, Lebanon, NH, USA.
出版信息
J Am Acad Dermatol. 2007 May;56(5):781-5. doi: 10.1016/j.jaad.2006.11.038. Epub 2007 Jan 29.
BACKGROUND
Tea constituents, including polyphenols, are hypothesized to have chemopreventive properties, and inhibit the induction of skin cancers in animal models.
OBJECTIVE
To explore the association between regular tea consumption (>or=1 cup/d for >or=1 month) and the incidence of squamous cell (SCC) and basal cell (BCC) carcinomas.
METHODS
A population-based case-control study of 770 individuals with BCC, 696 with SCC, and 715 age- and sex-matched control subjects.
RESULTS
After adjustment for age, sex, and lifetime history of painful sunburns, ever having consumed tea regularly was associated with a significantly lower risk of SCC (odds ratio [OR] = 0.70; 95% confidence interval [CI] 0.53-0.92), especially among long-term drinkers (>or=47 years consumption: SCC, OR = 0.49; 95% CI 0.29-0.83; P for trend = .008) and among those consuming >or=2 cups/d (OR = 0.65; 95% CI 0.44-0.96; P for trend = 0.013). After adjustment for age and sex, ever having consumed tea regularly was weakly associated with BCC risk (OR = 0.79; 95% CI 0.63-0.98).
LIMITATIONS
Our case-control study was susceptible to recall bias and to confounding by unknown cancer risk factors associated with tea consumption.
CONCLUSIONS
Our findings support the existence of an inverse association between tea consumption and skin carcinogenesis.
背景
茶的成分，包括多酚，被认为具有化学预防特性，并能在动物模型中抑制皮肤癌的诱发。
目的
探讨经常饮茶（≥1杯/天，持续≥1个月）与鳞状细胞癌（SCC）和基底细胞癌（BCC）发病率之间的关联。
方法
一项基于人群的病例对照研究，纳入770例BCC患者、696例SCC患者以及715例年龄和性别匹配的对照者。
结果
在对年龄、性别和晒伤史进行校正后，经常饮茶与SCC风险显著降低相关（比值比[OR]=0.70；95%置信区间[CI]0.53-0.92），尤其是在长期饮茶者中（饮茶≥47年：SCC，OR=0.49；95%CI 0.29-0.83；趋势检验P值=.008）以及每天饮茶≥2杯者中（OR=0.65；95%CI 0.44-0.96；趋势检验P值=0.013）。在对年龄和性别进行校正后，经常饮茶与BCC风险呈弱相关（OR=0.79；95%CI 0.63-0.98）。
局限性
我们的病例对照研究易受回忆偏倚影响，并易受与饮茶相关的未知癌症风险因素的混杂影响。
结论
我们的研究结果支持饮茶与皮肤癌发生之间存在负相关。
Zotero 插件