Zanetti R, Rosso S, Martinez C, Navarro C, Schraub S, Sancho-Garnier H, Franceschi S, Gafà L, Perea E, Tormo M J, Laurent R, Schrameck C, Cristofolini M, Tumino R, Wechsler J
Registro de Càncer de Granada, Escuela Andaluza de Salud Publica, Spain.
Br J Cancer. 1996 Jun;73(11):1440-6. doi: 10.1038/bjc.1996.274.
The aim of this study was to investigate constitutional and environmental determinants of non-melanocytic skin cancer among different populations from south Europe. Between 1989 and 1993 we interviewed incident cases and a random population sample of controls from five centres where a cancer registry was operating, whereas we selected a sample of hospital-based cases and controls from three other centres. Controls were stratified according to the age and sex distribution of cases. In all, 1549 cases of basal cell carcinoma (BCC), 228 of squamous cell carcinoma (SCC) and 1795 controls were interviewed. Both cancers affected primarily sun-exposed sites such as face, head and neck, but the prevalence of BCC on the trunk was higher than for SCC. Pigmentary traits such as hair and eye colour as well as tendency to sunburn were strong and independent indicators of risk for both BCC and SCC. In SCC, adjusted odds ratios (ORs) ranged from 1.6 for fair hair colour to 12.5 for red hair. Light-blonde hair entailed a risk of about 2 for BCC. Pale eye colour was associated with a risk of 1.8 for SCC and 1.4 for BCC. Subjects who always burn and never tan showed an adjusted OR of 2.7 for BCC and 2.0 for SCC. A history of sunburns and a young age at first sunburn were associated with an increased risk for BCC only (OR 1.7). Pigmentary traits and sun sensitivity of the skin confirmed their role as risk indicators. The effect of sunburns, as an indicator of both exposure and sun sensitivity of the skin, is less clear. Nevertheless, its association with BCC suggests, by analogy with melanoma, a relationship with intense sun exposure. Conversely, SCC would require prolonged exposure to sunlight.
本研究的目的是调查南欧不同人群中非黑素细胞性皮肤癌的体质和环境决定因素。1989年至1993年间，我们对来自五个设有癌症登记处的中心的新发病例和随机抽取的对照人群样本进行了访谈，同时从其他三个中心选取了一组基于医院的病例和对照样本。对照根据病例的年龄和性别分布进行分层。总共对1549例基底细胞癌（BCC）、228例鳞状细胞癌（SCC）和1795名对照进行了访谈。两种癌症主要累及面部、头部和颈部等阳光暴露部位，但BCC在躯干上的患病率高于SCC。头发和眼睛颜色等色素特征以及晒伤倾向是BCC和SCC风险的强有力且独立的指标。在SCC中，调整后的比值比（OR）范围从金发的1.6到红发的12.5。浅金色头发的BCC风险约为2。浅色眼睛与SCC风险1.8和BCC风险1.4相关。总是晒伤且从不晒黑的受试者，BCC的调整后OR为2.7，SCC为2.0。晒伤史和首次晒伤时年龄较小仅与BCC风险增加相关（OR 1.7）。皮肤的色素特征和阳光敏感性证实了它们作为风险指标的作用。晒伤作为皮肤暴露和阳光敏感性的指标，其影响尚不清楚。然而，它与BCC的关联通过与黑色素瘤类比，表明与强烈阳光暴露有关。相反，SCC则需要长时间暴露于阳光下。
