英国基底细胞癌的流行病学：发病率、生活方式因素及合并症
Epidemiology of basal cell carcinoma in the United Kingdom: incidence, lifestyle factors, and comorbidities.
作者信息
Reinau D, Surber C, Jick S S, Meier C R
机构信息
1] Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Spitalstrasse 26, Basel CH-4031, Switzerland [2] Hospital Pharmacy, University Hospital Basel, Basel, Switzerland.
Department of Dermatology, University Hospital Basel, Basel, Switzerland.
出版信息
Br J Cancer. 2014 Jul 8;111(1):203-6. doi: 10.1038/bjc.2014.265. Epub 2014 May 29.
BACKGROUND
Little is known about the epidemiology of basal cell carcinoma (BCC).
METHODS
Using the Clinical Practice Research Datalink, we calculated annual incidence rates. In a case-control analysis, we examined lifestyle factors and comorbidities.
RESULTS
Incidence rose significantly between 2000 and 2011. Basal cell carcinoma risk was increased in alcohol drinkers (slightly) and immunocompromised patients, but reduced in smokers and individuals with abnormal weight.
CONCLUSIONS
Basal cell carcinoma places a growing public health burden. Lifestyle factors do not play a major role in pathogenesis, but immunosuppression is important.
背景
关于基底细胞癌（BCC）的流行病学知之甚少。
方法
利用临床实践研究数据链，我们计算了年发病率。在一项病例对照分析中，我们研究了生活方式因素和合并症。
结果
2000年至2011年间发病率显著上升。饮酒者（略有增加）和免疫功能低下患者患基底细胞癌的风险增加，但吸烟者和体重异常者的风险降低。
结论
基底细胞癌给公共卫生带来了日益沉重的负担。生活方式因素在发病机制中不起主要作用，但免疫抑制很重要。
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