Villegas Maria Virginia, Lolans Karen, Correa Adriana, Kattan Juan Nicolas, Lopez Jaime A, Quinn John P
CIDEIM, International Center for Medical Research and Training, Cali, Colombia.
Antimicrob Agents Chemother. 2007 Apr;51(4):1553-5. doi: 10.1128/AAC.01405-06. Epub 2007 Jan 29.
In Medellin, Colombia, three Pseudomonas aeruginosa isolates with high-level carbapenem resistance (MIC>or=256 microg/ml) and an isolate of Citrobacter freundii with reduced susceptibility to imipenem produced the plasmid-mediated class A carbapenemase KPC-2. This is the first report of a KPC-type beta-lactamase identified outside of the family Enterobacteriaceae.
在哥伦比亚麦德林,三株对碳青霉烯类药物具有高水平耐药性(MIC≥256微克/毫升)的铜绿假单胞菌分离株以及一株对亚胺培南敏感性降低的弗氏柠檬酸杆菌分离株产生了质粒介导的A类碳青霉烯酶KPC-2。这是在肠杆菌科以外鉴定出的KPC型β-内酰胺酶的首次报道。