Kim S J, Lee S H, Kim I S, Kim H J, Kim S K, Rieder H L
International Union Against Tuberculosis and Lung Disease (The Union), Paris, France.
Int J Tuberc Lung Dis. 2007 Feb;11(2):138-42.
Mycobacteriology laboratories in the National Tuberculosis Control Programme in Korea.
To determine tuberculosis (TB) risk by type of work among laboratory workers compared to non-laboratory workers.
Retrospective study of TB incidence among technicians involved in acid-fast bacilli smear microscopy or culture and/or drug susceptibility testing (DST) compared with that among managerial/clerical workers.
Two cases developed among 77 non-laboratory workers, two among 88 smear microscopy technicians, and 11 among 76 culture/DST technicians during the observation period. Compared to non-laboratory workers, the relative risk of TB was 1.4 (95% CI 0.2-10.0) among microscopy technicians and 7.8 (95% CI 1.7-34.9) among culture/DST technicians. TB developed among 7/15 DST technicians compared to only 2/59 culture/non-DST technicians. Compared to non-laboratory workers, the relative risk for DST technicians was 21.5 (95% CI 4.5-102.5).
DST led to the highest relative risk among all types of mycobacteriology work, while performing smear microscopy alone did not pose an elevated risk compared to clerical work.
韩国国家结核病控制项目中的分枝杆菌学实验室。
与非实验室工作人员相比，确定实验室工作人员按工作类型划分的结核病（TB）风险。
对参与抗酸杆菌涂片显微镜检查或培养和/或药物敏感性试验（DST）的技术人员与管理/文书工作人员的结核病发病率进行回顾性研究。
在观察期内，77名非实验室工作人员中有2例发病，88名涂片显微镜检查技术人员中有2例发病，76名培养/DST技术人员中有11例发病。与非实验室工作人员相比，显微镜检查技术人员患结核病的相对风险为1.4（95%可信区间0.2 - 10.0），培养/DST技术人员为7.8（95%可信区间1.7 - 34.9）。15名DST技术人员中有7例发病，而59名培养/非DST技术人员中只有2例发病。与非实验室工作人员相比，DST技术人员的相对风险为21.5（95%可信区间4.5 - 102.5）。
在所有类型的分枝杆菌学工作中，DST导致的相对风险最高，而单独进行涂片显微镜检查与文书工作相比并未带来更高风险。
