Genechip 与常规药敏试验检测中国耐多药结核病的成本效益比较。
Cost-effectiveness comparison of Genechip and conventional drug susceptibility test for detecting multidrug-resistant tuberculosis in China.
机构信息
Chinese Center for Disease Control and Prevention, Beijing, China.
出版信息
PLoS One. 2013 Jul 23;8(7):e69267. doi: 10.1371/journal.pone.0069267. Print 2013.
BACKGROUND
Genechip (CapitalBio, Beijing, China) is a system for diagnosing resistance to rifampin and isoniazid, which shows high efficiency in detecting drug-resistant tuberculosis. Here, we firstly evaluated the costs of Genechip for detecting the drug susceptibility of Mycobacterium tuberculosis, compared to conventional drug susceptibility test (DST) in laboratories in China.
METHODOLOGY/PRINCIPAL FINDINGS: Data on the costs of the two tests were collected at four hospitals. Costs were calculated using the essential factor cost calculation method. The costs of diagnosing a single case of multidrug-resistant tuberculosis (MDR-TB) using Genechip and DST were US$22.38 and $53.03, respectively. Taking into account the effect on costs from failure of a certain number of tests to accurately diagnose MDR-TB, the costs of Genechip and DST increased by 17.65% and 5.22%, respectively. The cost of both tests decreased with the increasing prevalence of MDR-TB disease, and the cost of Genechip at a sensitivity of more than 50% was lower than that of DST. When price of Genechip was varied to 50%, 80%, 150%, and 200% of the original price, the cost of Genechip at sensitivities of more than 30%, 40%, 60%, and 70%, respectively, was also lower than that of DST.
CONCLUSIONS/SIGNIFICANCE: This study showed that Genechip was a more cost-effective method of diagnosing MDR-TB compared to conventional DST.
背景
Genechip（北京博奥晶典生物技术有限公司）是一种用于检测利福平及异烟肼耐药性的系统，在检测耐药性结核方面具有较高的效率。在此，我们首次评估了 Genechip 检测结核分枝杆菌药物敏感性的成本，与中国实验室常规药物敏感性试验（DST）相比。
方法/主要发现：在四家医院收集了两种测试的成本数据。采用必需要素成本计算法计算成本。使用 Genechip 和 DST 诊断一例耐多药结核病（MDR-TB）的成本分别为 22.38 美元和 53.03 美元。考虑到某些测试未能准确诊断 MDR-TB 对成本的影响，Genechip 和 DST 的成本分别增加了 17.65%和 5.22%。随着 MDR-TB 疾病流行率的增加，两种测试的成本都有所降低，而 Genechip 在灵敏度超过 50%时的成本低于 DST。当 Genechip 的价格变化为原价的 50%、80%、150%和 200%时，灵敏度分别超过 30%、40%、60%和 70%的 Genechip 的成本也低于 DST。
结论/意义：本研究表明，与传统 DST 相比，Genechip 是一种更具成本效益的 MDR-TB 诊断方法。
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