Vigorito Carlo, Giallauria Francesco, Palomba Stefano, Cascella Teresa, Manguso Francesco, Lucci Rosa, De Lorenzo Anna, Tafuri Domenico, Lombardi Gaetano, Colao Annamaria, Orio Francesco
Department of Clinical Medicine, University Federico II of Naples, Italy.
J Clin Endocrinol Metab. 2007 Apr;92(4):1379-84. doi: 10.1210/jc.2006-2794. Epub 2007 Jan 30.
Polycystic ovary syndrome (PCOS) is an endocrine disease closely related to several risk factors for cardiovascular disease. An impaired cardiopulmonary functional capacity was previously demonstrated in PCOS women. No data regarding the effects of a structured exercise training (ET) program on cardiopulmonary functional capacity in PCOS women are available.
Our objective was to evaluate the effects of a 3-month ET program on cardiopulmonary functional capacity in young PCOS women.
A prospective baseline-randomized clinical study was conducted at the University "Federico II" of Naples, School of Medicine (Italy).
Ninety young overweight PCOS women were enrolled.
Ninety young PCOS women were randomly subdivided into two groups, each composed of 45 subjects. The PCOS-T (trained) group underwent a 3-month structured ET program, whereas the PCOS-UnT (untrained) group did not. Hormonal and metabolic profiles and cardiopulmonary and exercise parameters were evaluated.
After 3-month ET, PCOS-T showed a significant improvement in peak oxygen consumption (+35.4%; P<0.001) and in maximal workload (+37.2%; P<0.001). In PCOS-T we also observed a significant reduction in body mass index (-4.5%; P<0.001) and in C-reactive protein (-10%; P<0.001), and a significant (P<0.001) improvement in insulin sensitivity indexes. After 3 months, no changes were observed in PCOS-UnT.
A 3-month structured ET program improves cardiopulmonary functional capacity in young PCOS women.
多囊卵巢综合征（PCOS）是一种与多种心血管疾病风险因素密切相关的内分泌疾病。先前已证实PCOS女性存在心肺功能受损。目前尚无关于结构化运动训练（ET）计划对PCOS女性心肺功能影响的数据。
我们的目的是评估为期3个月的ET计划对年轻PCOS女性心肺功能的影响。
在意大利那不勒斯“费德里科二世”大学医学院进行了一项前瞻性基线随机临床研究。
招募了90名年轻超重的PCOS女性。
90名年轻的PCOS女性被随机分为两组，每组45名受试者。PCOS-T（训练组）接受为期3个月的结构化ET计划，而PCOS-UnT（未训练组）则不接受。评估了激素和代谢谱以及心肺和运动参数。
经过3个月的ET后，PCOS-T组的峰值耗氧量显著改善（+35.4%；P<0.001），最大工作量显著改善（+37.2%；P<0.001）。在PCOS-T组中，我们还观察到体重指数显著降低（-4.5%；P<0.001）和C反应蛋白显著降低（-10%；P<0.001），以及胰岛素敏感性指数显著改善（P<0.001）。3个月后，PCOS-UnT组未观察到变化。
为期3个月的结构化ET计划可改善年轻PCOS女性的心肺功能。
