Giallauria Francesco, Palomba Stefano, Maresca Luigi, Vuolo Laura, Tafuri Domenico, Lombardi Gaetano, Colao Annamaria, Vigorito Carlo, Francesco Orio
Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University of Naples, Naples, Italy.
Clin Endocrinol (Oxf). 2008 Nov;69(5):792-8. doi: 10.1111/j.1365-2265.2008.03305.x. Epub 2008 May 23.
Polycystic ovary syndrome (PCOS) is a common female reproductive-age endocrine disease predominantly characterized by chronic anovulation, hyperandrogenism, insulin-resistance and low-grade inflammatory status. Exercise training (ET) favourably modulates cardiopulmonary function and insulin-sensitivity markers in PCOS women. The present study investigated the effects of ET on autonomic function and inflammatory pattern in PCOS women.
Prospective baseline uncontrolled clinical study.
One-hundred and eighty five PCOS women referred to our department were screened for the inclusion into the study protocol from March 2004 to July 2007. One-hundred and twenty four PCOS women met the criteria for the inclusion into the study protocol and were subdivided into two groups each composed of 62 patients: PCOS-T (trained) group underwent 3-month ET program, whereas PCOS-UnT (untrained) group did not. At baseline and at 3-month follow-up, hormonal and metabolic profile, cardiopulmonary parameters, autonomic function (as expressed by heart rate recovery, HRR) and inflammatory pattern [as expressed by C-reactive protein (CRP) and white blood cells (WBCs) count] were evaluated.
PCOS-T showed a significant (P < 0.05) improvement in maximal oxygen consumption (VO(2max)) and in post-exercise HRR, and a significant (P < 0.001) decrease in CRP and WBCs; whereas no statistically significant changes of the same parameters were observed in PCOS-UnT. Multiple linear regression analysis showed that 3-month HRR is linearly related to the inclusion in training group (beta = 0.316, P < 0.001), VO(2max) (beta = 0.151, P = 0.032) and the ratio between glucose and insulin area under curve (AUC) (beta = 0.207, P = 0.003), and inversely related to body mass index (beta = -0.146, P = 0.046), insulin AUC (beta = -0.152, P = 0.032), CRP (beta = -0.165, P < 0.021), and WBCs count (beta = -0.175, P = 0.039).
Exercise training improves autonomic function and inflammatory pattern in PCOS women.
多囊卵巢综合征（PCOS）是一种常见的育龄期女性内分泌疾病，主要特征为慢性无排卵、高雄激素血症、胰岛素抵抗和低度炎症状态。运动训练（ET）可对PCOS女性的心肺功能和胰岛素敏感性标志物产生有益调节作用。本研究调查了ET对PCOS女性自主神经功能和炎症模式的影响。
前瞻性基线非对照临床研究。
2004年3月至2007年7月，对转诊至我科的185例PCOS女性进行筛选以纳入研究方案。124例PCOS女性符合纳入研究方案的标准，被分为两组，每组62例患者：PCOS-T（训练）组接受为期3个月的ET方案，而PCOS-UnT（未训练）组未接受。在基线和3个月随访时，评估激素和代谢指标、心肺参数、自主神经功能（以心率恢复，HRR表示）和炎症模式[以C反应蛋白（CRP）和白细胞（WBC）计数表示]。
PCOS-T组在最大摄氧量（VO₂max）和运动后HRR方面有显著（P < 0.05）改善，CRP和WBC有显著（P < 0.001）下降；而PCOS-UnT组相同参数未观察到统计学显著变化。多元线性回归分析显示，3个月时的HRR与纳入训练组（β = 0.316，P < 0.001）、VO₂max（β = 0.151，P = 0.032）以及葡萄糖与胰岛素曲线下面积（AUC）之比（β = 0.207，P = 0.003）呈线性相关，与体重指数（β = -0.146，P = 0.046）、胰岛素AUC（β = -0.
