Koh T, Nakazawa M, Kani K, Maeda T
Department of Ophthalmology, Shiga University of Medical Science.
J Hirnforsch. 1991;32(6):707-14.
The present study investigated the distribution of serotonergic and non-serotonergic raphe neurons with direct projections to the visual cortex. The study employed the WGA-apoHRP-Au retrograde transport technique combined with 5-HT immunohistochemical staining. Retrogradely labeled cells were observed in the dorsal raphe nucleus, the median raphe nucleus, and in the B9 and B6 cell groups. One notable finding was the great number of retrogradely labeled, non-5-HT immunoreactive cells. The average percentages of such cells in the various raphe regions were as follows: DR: 52% (n = 401); MR: 35% (n = 311); B9: 24% (n = 129); B6: 95% (n = 200). The present study demonstrated the presence of a significant proportion of non-serotonergic raphe region neurons projecting to the primary visual cortex in the rat. It is suggested that these neurons may complement the aminergic neurons as part of the ascending system which controls the functions of the visual cortex.
本研究调查了直接投射到视觉皮层的血清素能和非血清素能中缝神经元的分布。该研究采用了WGA-apoHRP-Au逆行运输技术结合5-羟色胺免疫组织化学染色。在中缝背核、中缝正中核以及B9和B6细胞群中观察到逆行标记的细胞。一个值得注意的发现是大量逆行标记的、非5-羟色胺免疫反应性细胞。这些细胞在各个中缝区域的平均百分比如下：中缝背核：52%（n = 401）；中缝正中核：35%（n = 311）；B9：24%（n = 129）；B6：95%（n = 200）。本研究证明在大鼠中，有相当比例的非血清素能中缝区域神经元投射到初级视觉皮层。有人提出，这些神经元可能作为控制视觉皮层功能的上行系统的一部分，补充胺能神经元的作用。
