Trost Barry M, Dogra Kalindi
Department of Chemistry, Stanford University, Stanford, California 94305, USA.
Org Lett. 2007 Mar 1;9(5):861-3. doi: 10.1021/ol063022k. Epub 2007 Feb 1.
[reaction: see text] Delta9-THC is synthesized in enantiomericaly pure form, where all of the stereochemistry is derived from the molybdenum-catalyzed asymmetric alkylation reaction of the extremely sterically congested bis-ortho-substituted cinnamyl carbonate in high regio- and enantioselectivity.
[反应:见正文] Δ⁹-四氢大麻酚以对映体纯形式合成,其所有立体化学均源自极度空间拥挤的双邻位取代肉桂酸酯的钼催化不对称烷基化反应,该反应具有高区域选择性和对映选择性。