Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Chemistry. 2012 Sep 17;18(38):11880-3. doi: 10.1002/chem.201202251. Epub 2012 Aug 21.
A highly efficient, regio- and enantioselective Cu(I)/phosphoramidite-catalyzed asymmetric allylic alkylation of allyl ethers with organolithium reagents is reported (see scheme). The use of organolithium reagents is essential for this catalytic C-C bond formation due to their compatibility with different Lewis acids. The versatility of allylic ethers under the copper-catalyzed reaction conditions with organolithium reagents is demonstrated in the shortest synthesis of (S)-Arundic acid.
本文报道了一种高效、区域和对映选择性的铜（I）/磷酰胺催化剂促进的烯丙基醚与有机锂试剂的不对称烯丙基烷基化反应（见方案）。由于其与不同路易斯酸的兼容性，有机锂试剂对于这种催化 C-C 键形成是必不可少的。在铜催化的与有机锂试剂的反应条件下，烯丙基醚的多功能性在（S）-芦竹碱的最短合成中得到了证明。
