Gamboa P M, Sanz M L, de la Cuesta C G, García B E, Castillo J G, Oehling A
Departamento de Alergología e Inmunología Clínica, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
J Investig Allergol Clin Immunol. 1991 Feb;1(1):59-67.
This study was carried out on 96 atopic patients with monosensitization against Dermatophagoides pteronyssinus and 30 control individuals. The patients were divided into 3 subgroups: 27 asymptomatic patients, 27 patients who only presented nasal symptomatology, and 27 patients with marked bronchial symptomatology. Total serum IgE, antigen-specific histamine release, and the number of beta 2-adrenergic receptors in peripheral blood lymphocytes in all patients were determined. The control group presented the highest number of beta-receptors in comparison with the bronchial symptomatic and nasal symptomatic patients. However, asymptomatic patients presented numbers of beta-receptors similar to controls, with no significant differences between both groups. No significant correlation was found between beta-adrenergic receptors and levels of total serum IgE. On the other hand, correlation between beta-receptors and specific histamine release was detected only in symptomatic nasal patients. It can be postulated that the decrease in beta-receptors is a consequence, and not the cause, of atopy.
本研究对96例对尘螨单致敏的特应性患者和30例对照个体进行。患者被分为3个亚组：27例无症状患者、27例仅表现出鼻部症状的患者和27例有明显支气管症状的患者。测定了所有患者的血清总IgE、抗原特异性组胺释放以及外周血淋巴细胞中β2 - 肾上腺素能受体的数量。与有支气管症状和鼻部症状的患者相比，对照组的β受体数量最多。然而，无症状患者的β受体数量与对照组相似，两组之间无显著差异。β - 肾上腺素能受体与血清总IgE水平之间未发现显著相关性。另一方面，仅在有症状的鼻部患者中检测到β受体与特异性组胺释放之间的相关性。可以推测，β受体的减少是特应性的结果而非原因。
