Gamboa P M, Oehling A, Sanz M L, Castillo J G
Allergol Immunopathol (Madr). 1987 Mar-Apr;15(2):65-8.
The number of beta-receptors was determined in 60 atopic patients: 30 asthmatics with sensitization to domestic inhalant allergens and 30 rhinitic patients with sensitization to pollen and/or Dermatophagoides antigens. A L-iodocyanopindolol radio-active marker was used. Our control population (20 healthy individuals) showed 908 +/- 396 receptors/cell. The rhinitic individuals showed a 24% decrease in receptors in relation to the control population. On the other hand, within the asthmatic patients there existed 2 differentiated groups: inactive asthmatics whose receptors were found to be within the normal limits and active asthmatics with a 36% decrease in receptors in relation to the healthy individuals (673 receptors/cell) establishing a significant statistical difference (p less than 0.005). As a consequence these data seem to support Szentivanyi's B-adrenoreceptor theory.
对60名特应性患者测定了β受体数量：30名对室内吸入性变应原致敏的哮喘患者和30名对花粉和/或尘螨抗原致敏的鼻炎患者。使用了L-碘氰吲哚洛尔放射性标记物。我们的对照人群（20名健康个体）显示有908±396个受体/细胞。鼻炎患者的受体数量相对于对照人群减少了24%。另一方面，在哮喘患者中存在2个不同的组：非活动期哮喘患者的受体数量在正常范围内，而活动期哮喘患者的受体数量相对于健康个体减少了36%（673个受体/细胞），存在显著的统计学差异（p<0.005）。因此，这些数据似乎支持森蒂瓦尼的β-肾上腺素能受体理论。
