Hardy R G, Forsythe J L R
Edinburgh Breast Unit, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, United Kingdom.
Thyroid. 2007 Jan;17(1):63-5. doi: 10.1089/thy.2006.0221.
Serious wound infection after thyroidectomy is uncommon, but actual incidence is not well documented in the literature. In the past a patient in our unit died secondary to fulminant streptococcal sepsis after thyroidectomy for benign disease. This prompted us to audit experience of serious wound infection among British Association of Endocrine Surgery (BAES) members.
A questionnaire was posted to BAES members inquiring about experience of major wound infection following cervicotomy, incidence of minor wound infection, and prophylactic and therapeutic antibiotic usage.
Eight respondents experienced a case of fulminant wound infection after cervicotomy (8% total respondents). Five patients died and, in 6 patients, cases of streptococci were cultured. Then, 9% of respondents used prophylactic antibiotics routinely, 16% sometimes and 75% never. The most commonly used antibiotic was augmentin, and the most common reasons for use among those with a selective policy were re-operative cases (38%) and immunocompromised patients (38%). Also, 40% of respondents experienced major wound infection requiring intravenous antibiotics or surgical drainage. The most common choices of antibiotic used before sensitivities were obtained were augmentin (43%) and flucloxacillin (35%).
Although rare, fulminant streptococcal wound infection after cervicotomy does occasionally occur and carries a high mortality.
甲状腺切除术后严重伤口感染并不常见,但文献中对其实际发生率的记载并不充分。过去,我们科室有一名患者在因良性疾病接受甲状腺切除术后,继发暴发性链球菌败血症死亡。这促使我们对英国内分泌外科协会(BAES)成员中严重伤口感染的经验进行审查。
向BAES成员发放问卷,询问其颈部切开术后重大伤口感染的经验、轻微伤口感染的发生率以及预防性和治疗性抗生素的使用情况。
8名受访者经历过颈部切开术后暴发性伤口感染病例(占总受访者的8%)。5名患者死亡,6名患者培养出链球菌病例。此外,9%的受访者常规使用预防性抗生素,16%有时使用,75%从不使用。最常用的抗生素是阿莫西林克拉维酸钾,在采取选择性用药策略的受访者中,最常见的用药原因是再次手术病例(38%)和免疫功能低下患者(38%)。另外,40%的受访者经历过需要静脉使用抗生素或手术引流的重大伤口感染。在获得药敏结果之前,最常用的抗生素选择是阿莫西林克拉维酸钾(43%)和氟氯西林(35%)。
尽管罕见,但颈部切开术后暴发性链球菌伤口感染确实偶尔会发生,且死亡率很高。