血小板与阿尼芬净对烟曲霉的相互作用。
Interaction of platelets and anidulafungin against Aspergillus fumigatus.
机构信息
University of Applied Sciences Tyrol, Innsbruck, Austria.
出版信息
Antimicrob Agents Chemother. 2013 Jan;57(1):626-8. doi: 10.1128/AAC.01534-12. Epub 2012 Oct 31.
Abstract
The combination of platelets and anidulafungin at 0.03 μg/ml significantly (P < 0.05) reduced the germination rate and hyphal elongation in Aspergillus fumigatus compared to those with either anidulafungin only or an untreated control. Platelets decreased the expression of the fks gene, which plays an important role in cell wall synthesis. Our results suggest that human platelets plus anidulafungin might contribute to defense against A. fumigatus.
摘要
血小板与安尼拉fungin 在 0.03μg/ml 联合显著（P<0.05）降低了烟曲霉菌的发芽率和菌丝伸长率，与仅用安尼拉fungin 或未处理的对照组相比。血小板降低了 fks 基因的表达，该基因在细胞壁合成中起重要作用。我们的结果表明，人血小板加安尼拉fungin 可能有助于对抗烟曲霉菌。
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