Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
J Neurogastroenterol Motil. 2012 Jul;18(3):284-90. doi: 10.5056/jnm.2012.18.3.284. Epub 2012 Jul 10.
BACKGROUND/AIMS: In Asian countries including Korea, the prevalence of gastroesophageal reflux disease (GERD) is on the rise and its clinical impact has been emphasized. The purpose of this study was to investigate the clinical characteristics of esophagitis patients with or without symptoms, and their association with psychological factors.
Subjects diagnosed as erosive esophagitis of Los Angeles-A or more in screening by upper gastrointestinal endoscopy were enrolled. Questionnaires regarding GERD symptoms and Symptom Checklist-90-Revision were used to identify the presence of psychological symptoms.
There was no difference between the subjects' general characteristics (gender, age, body mass index, smoking and alcohol intake) according to the existence of typical symptoms in these patients with erosive esophagitis. Patients with typical GERD symptoms were more likely to have atypical symptoms, dyspepsia and higher scores on psychological symptoms (somatization, obsessive-compulsiveness and phobic anxiety) than those without.
Psychological symptoms and other gastrointestinal symptoms should be considered in the patients with erosive esophagitis.
背景/目的：在包括韩国在内的亚洲国家，胃食管反流病（GERD）的患病率呈上升趋势，其临床影响已受到重视。本研究旨在探讨有或无症状食管炎患者的临床特征及其与心理因素的关系。
通过上消化道内镜检查筛选出洛杉矶 A 级或更高级别的糜烂性食管炎患者作为研究对象。使用 GERD 症状问卷和症状清单 90 修订版（Symptom Checklist-90-Revision）来确定是否存在心理症状。
在这些有糜烂性食管炎的患者中，根据是否存在典型症状，其一般特征（性别、年龄、体重指数、吸烟和饮酒）无差异。有典型 GERD 症状的患者比没有典型 GERD 症状的患者更有可能出现非典型症状、消化不良和更高的心理症状评分（躯体化、强迫观念和恐惧症焦虑）。
在有糜烂性食管炎的患者中，应考虑心理症状和其他胃肠道症状。
