Keoleian G M, Pach J M, Hodge D O, Trocme S D, Bourne W M
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905.
Am J Ophthalmol. 1992 Jan 15;113(1):64-70. doi: 10.1016/s0002-9394(14)75755-1.
We performed specular microscopy, anterior segment ocular fluorophotometry, corneal pachymetry, and tonometry on 14 patients with chronic type I diabetes and nonproliferative retinopathy and on 14 age-matched control subjects. The eyes of patients with diabetes had an increased coefficient of variation of endothelial cell area, a decreased percentage of hexagonal endothelial cells, increased corneal autofluorescence, and increased intraocular pressure, which confirmed previous studies. There was no difference, however, in corneal thickness or endothelial permeability to fluorescein. Thus, we were unable to detect any abnormality in endothelial function in these diabetic corneas in the unstressed state, despite structurally abnormal endothelial cells.
我们对14例患有慢性I型糖尿病和非增殖性视网膜病变的患者以及14名年龄匹配的对照受试者进行了镜面显微镜检查、眼前段眼荧光光度测定、角膜测厚和眼压测量。糖尿病患者的眼睛内皮细胞面积变异系数增加、六边形内皮细胞百分比降低、角膜自发荧光增加以及眼压升高，这证实了先前的研究。然而，角膜厚度或内皮细胞对荧光素的通透性并无差异。因此，尽管内皮细胞结构异常，但我们在这些处于非应激状态的糖尿病角膜中未能检测到内皮功能的任何异常。
