Dubovsky S L, Lee C, Christiano J, Murphy J
Department of Psychiatry, University of Colorado School of Medicine, Denver.
Biol Psychiatry. 1991 Mar 1;29(5):441-50. doi: 10.1016/0006-3223(91)90266-o.
Baseline and thrombin-stimulated free intracellular calcium concentrations in blood platelets were significantly higher in untreated depressed bipolar patients than in untreated unipolar depressed patients or controls. Platelet intracellular calcium ion concentrations in euthymic-treated bipolar patients were equivalent to control values, suggesting but not proving a state-dependent change in intracellular calcium ion dynamics in bipolar depression. Unipolar and some subsets of bipolar patients appear not to exhibit this change.
未治疗的双相抑郁患者血小板的基线及凝血酶刺激后的细胞内游离钙浓度显著高于未治疗的单相抑郁患者或对照组。经治疗处于心境正常状态的双相患者血小板细胞内钙离子浓度与对照组相当，这提示但未证实双相抑郁患者细胞内钙离子动力学存在状态依赖性变化。单相患者及双相患者的某些亚组似乎未表现出这种变化。
