潜伏性结核病韦恩模型的体内适应性
In vivo adaptation of the Wayne model of latent tuberculosis.
作者信息
Woolhiser Lisa, Tamayo Marcela Henao, Wang Baolin, Gruppo Veronica, Belisle John T, Lenaerts Anne J, Basaraba Randall J, Orme Ian M
机构信息
Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
出版信息
Infect Immun. 2007 May;75(5):2621-5. doi: 10.1128/IAI.00918-06. Epub 2007 Feb 5.
Abstract
Cultures of Mycobacterium tuberculosis grown under oxygen depletion conditions enter into a state of nonreplicating persistence that may reflect a physiologically latent state. When these cultures were harvested and injected intranasally into mice, no bacteria could be recovered from the lungs for about 3 weeks, but after that evidence of regrowth was observed. Preimmunization of mice with a panel of selected vaccine candidates slowed or prevented this event. This simple model has potential for identifying vaccines targeting latent tuberculosis.
摘要
在缺氧条件下培养的结核分枝杆菌进入一种非复制性持续状态，这可能反映了一种生理潜伏状态。当收获这些培养物并经鼻内注射到小鼠体内时，在大约3周内肺部未检测到细菌，但之后观察到有细菌再生长的迹象。用一组选定的候选疫苗对小鼠进行预免疫可减缓或阻止这一现象。这个简单的模型有潜力识别针对潜伏性结核病的疫苗。
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