Dancause Numa
Department of Neurology, University of Rochester Medical Center, 601 Elmwood Ave, Box 673, Rochester, NY 14642, USA.
Rev Neurosci. 2006;17(6):561-80. doi: 10.1515/revneuro.2006.17.6.561.
Evidence supporting the plastic capacity of the adult cortex is abundant. Changes have been associated with exposure to enriched environments, learning, peripheral lesions and central lesions. The initial loss of function caused by a lesion is generally followed by a certain amount of recovery that is believed to be due, at least in part, to adaptive plasticity. In particular, the reorganization of cortical representational maps has been associated with improvement of performance. Therefore, areas undergoing such reorganization following lesions are generally assumed to participate in the recovery. We review evidence demonstrating the remodeling of representational maps of the forelimb in adult cortex and the structural plasticity that has been coupled with it. A particular emphasis is paid to non-human primate studies and stroke.
支持成年皮质可塑性的证据非常丰富。这些变化与置身丰富环境、学习、外周损伤和中枢损伤有关。损伤导致的功能最初丧失之后，通常会有一定程度的恢复，人们认为这至少部分归因于适应性可塑性。特别是，皮质表征图谱的重组与行为表现的改善有关。因此，损伤后发生这种重组的区域通常被认为参与了恢复过程。我们综述了证明成年皮质前肢表征图谱重塑及其相关结构可塑性的证据。特别强调了非人类灵长类动物研究和中风研究。
