Ruffault A, Fauconnier B, Cartier F, Launois B
Pathol Biol (Paris). 1975 May;23(5):371-4.
The titer of circulating antibodies to herpes simplex virus type 1 was tested in 18 patients for a few months before and after renal transplantation. No clinical illness was observed in the group of patients lacking antibodies. On the contrary, half of those with antibodies developed cutaneous eruption within 2 to 4 weeks following treatment with immunosuppressive drugs. No relationship could be found between the appearance of clinical illness and the rise in antibody titer. This lack of correlation could be explained by the multiple modifications occurring in the immune system of the host submitted to immunosuppressive drugs.
在18例肾移植患者肾移植前后的几个月内，检测了他们针对1型单纯疱疹病毒的循环抗体滴度。在缺乏抗体的患者组中未观察到临床疾病。相反，在接受免疫抑制药物治疗后的2至4周内，有抗体的患者中有一半出现了皮疹。临床疾病的出现与抗体滴度的升高之间未发现相关性。这种缺乏相关性的现象可以用接受免疫抑制药物治疗的宿主免疫系统中发生的多种变化来解释。
