Majoul Irina, Shirao Tomoaki, Sekino Yuko, Duden Rainer
School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey, TW20 0EX, UK.
Histochem Cell Biol. 2007 Apr;127(4):355-61. doi: 10.1007/s00418-007-0273-y. Epub 2007 Feb 7.
In this review we consider the multiple functions of developmentally regulated brain protein (drebrin), an actin-binding protein, in the formation of cellular polarity in different cell types. Drebrin has a well-established role in the morphogenesis, patterning and maintenance of dendritic spines in neurons. We have recently shown that drebrin also stabilizes Connexin-43 containing gap junctions at the plasma membrane. The latest literature and our own data suggest that drebrin may be broadly involved in shaping cell processes and in the formation of stabilized plasma membrane domains, an effect that is likely to be of crucial significance for formation of cell polarity in both neuronal and non-neuronal types.
在本综述中，我们探讨了发育调控脑蛋白（drebrin）（一种肌动蛋白结合蛋白）在不同细胞类型中细胞极性形成过程中的多种功能。Drebrin在神经元树突棘的形态发生、模式形成和维持方面具有既定作用。我们最近发现，drebrin还能稳定质膜上含连接蛋白43的间隙连接。最新文献和我们自己的数据表明，drebrin可能广泛参与细胞突起的塑造以及稳定质膜结构域的形成，这一作用对于神经元和非神经元类型细胞极性的形成可能具有至关重要的意义。
