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人皮肤原发性淋巴管中黑色素瘤侵袭的超微结构研究

Ultrastructural studies on the invasion of melanomas in initial lymphatics of human skin.

作者信息

Deutsch A, Lubach D, Nissen S, Neukam D

机构信息

Department of Dermatology (Hautklinik Linden), Medizinische Hochschule Hannover, Federal Republic of Germany.

出版信息

J Invest Dermatol. 1992 Jan;98(1):64-7. doi: 10.1111/1523-1747.ep12495259.

DOI:10.1111/1523-1747.ep12495259
PMID:1728641
Abstract

The way in which melanoma cells invade the initial lymphatics of the skin was investigated in this study. Samples of sixty melanomas were examined by transmission electron microscopy. Tumor cells invading lymph vessels were demonstrated in 20 specimens. In most cases the melanomas penetrated the subendothelial space as single cells. These fused with the endothelial cytoplasmic membrane and subsequently destroyed the endothelial wall.

摘要

本研究对黑色素瘤细胞侵袭皮肤初始淋巴管的方式进行了调查。通过透射电子显微镜检查了60个黑色素瘤样本。在20个标本中发现了侵袭淋巴管的肿瘤细胞。在大多数情况下，黑色素瘤以单个细胞的形式穿透内皮下间隙。这些细胞与内皮细胞质膜融合，随后破坏内皮壁。

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