Shayan H, Kopac D, Sample C B
Centre for the Advancement of Minimally Invasive Surgery, University of Alberta, 205 Tawa Centre, 3017-66 Street, Edmonton, AB, Canada, T6K 4B2.
Surg Endosc. 2007 Sep;21(9):1549-52. doi: 10.1007/s00464-006-9169-5. Epub 2007 Feb 8.
Use of the standard management for gallstone-associated acute pancreatitis calls for cholecystectomy with cholangiography performed during the same hospitalization after acute symptoms has decreased. No previous studies, however, have objectively addressed the usefulness of intraoperative cholangiography (IOC) for the management of this condition. This study aimed to determine the incidence of common bile duct (CBD) stones after an acute episode of gallstone pancreatitis.
The medical records of all patients who underwent a cholecystectomy and IOC after an episode of gallstone pancreatitis during the same admission between 1999 and 2004 at the University of Alberta and Royal Alexandra hospitals were examined to determine the incidence of CBD stones after resolution of gallstone pancreatitis.
After a chart review for a series of 86 patients, 63 met the inclusion criteria. All except for one patient had undergone successful IOC (98%). Among the patients who had no evidence of CBD obstruction on preoperative imaging or lab work, three were found to have a filling defect on IOC and stones on their postoperative endoscopic retrograde cholangiopancreatography (ERCP) (3/63, 5%). This is not significantly different from the 4.6% incidence of CBD stones among patients with cholelithiasis who had normal preoperative imaging and blood work.
In the setting of normal preoperative imaging and lab work, the incidence of CBD stones among patients recovering from acute mild to moderate gallstone pancreatitis is not significantly higher than among patients with no history of pancreatitis. Therefore, an IOC for post-gallstone pancreatitis does not alter management.
对于胆石症相关性急性胰腺炎的标准治疗方法是,在急性症状缓解后的同一住院期间进行胆囊切除术并进行胆管造影。然而,此前尚无研究客观地探讨术中胆管造影(IOC)在这种疾病治疗中的作用。本研究旨在确定胆石性胰腺炎急性发作后胆总管(CBD)结石的发生率。
对1999年至2004年期间在阿尔伯塔大学和皇家亚历山德拉医院因胆石性胰腺炎发作后在同一住院期间接受胆囊切除术和IOC的所有患者的病历进行检查,以确定胆石性胰腺炎缓解后CBD结石的发生率。
对一系列86例患者的病历进行审查后,63例符合纳入标准。除1例患者外,所有患者的IOC均成功完成(98%)。在术前影像学检查或实验室检查未发现CBD梗阻证据的患者中,有3例在IOC检查中发现充盈缺损,并在术后经内镜逆行胰胆管造影(ERCP)检查中发现结石(3/63,5%)。这与术前影像学检查和血液检查正常的胆石症患者中CBD结石发生率4.6%无显著差异。
在术前影像学检查和实验室检查正常的情况下,从急性轻度至中度胆石性胰腺炎恢复的患者中CBD结石的发生率并不显著高于无胰腺炎病史的患者。因此,胆石性胰腺炎后的IOC不会改变治疗方案。