分子内PIFA介导的炔烃酰胺化和羧化反应。
Intramolecular PIFA-mediated alkyne amidation and carboxylation reaction.
作者信息
Tellitu Imanol, Serna Sonia, Herrero M Teresa, Moreno Isabel, Domínguez Esther, SanMartin Raul
机构信息
Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), P.O. Box 644, 48080 Bilbao, Spain.
出版信息
J Org Chem. 2007 Feb 16;72(4):1526-9. doi: 10.1021/jo062320s.
PMID:17288399
Abstract
The hypervalent iodine reagent PIFA promotes the intramolecular electrophilic cyclization of easily accessible alkynylamides and alkynyl carboxylic acids, leading to the formation of pyrrolidinone and lactone skeletons, respectively, in a very efficient way. A synthetic study and a mechanistic proposal for these transformations are presented.
摘要
高价碘试剂PIFA能高效地促进易于获得的炔基酰胺和炔基羧酸的分子内亲电环化反应，分别生成吡咯烷酮和内酯骨架。本文介绍了这些转化反应的合成研究和机理推测。
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