成年大鼠肝脏再生相关的特定内分泌和激素受体变化
Specific endocrine and hormonal receptor changes associated with liver regeneration in adult rats.
作者信息
Leffert H, Alexander N M, Faloona G, Rubalcava B, Unger R
出版信息
Proc Natl Acad Sci U S A. 1975 Oct;72(10):4033-6. doi: 10.1073/pnas.72.10.4033.
Abstract
Partial removal of the adult rat liver--a procedure that stimulates liver regeneration--causes arterial levels of insulin and thyroxin to fall and glucagon levels to rise. These changes are correlated with the quantity of liver tissue excised and not solely with nonspecific operative manipulations or with blood glucose levels. During regeneration (about 24 hr postoperatively), hepatic plasma membranes become partially resistant to binding glucagon; this change is specific because it is not detected in laparotomized controls and insulin binding is not significantly altered. It remains to be proven whether any one or more of these specific endocrine changes are casually related to the initiation of hepatic proliferation.
摘要
切除成年大鼠部分肝脏（这一操作可刺激肝脏再生）会导致动脉血中胰岛素和甲状腺素水平下降，胰高血糖素水平上升。这些变化与切除的肝组织量相关，而不仅仅与非特异性手术操作或血糖水平有关。在肝脏再生过程中（术后约24小时），肝细胞膜对胰高血糖素的结合变得部分抵抗；这种变化是特异性的，因为在仅做剖腹手术的对照动物中未检测到，且胰岛素结合未发生显著改变。这些特异性内分泌变化中的任何一种或多种是否与肝增殖的启动存在因果关系，仍有待证实。
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