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联合抗病毒治疗在大流行性流感中的作用及储备意义。

Role of combination antiviral therapy in pandemic influenza and stockpiling implications.

作者信息

Tsiodras Sotirios, Mooney John D, Hatzakis Angelos

机构信息

Fourth Academic Department of Internal Medicine, University of Athens Medical School, Athens 12462, Greece.

出版信息

BMJ. 2007 Feb 10;334(7588):293-4. doi: 10.1136/bmj.39105.428981.BE.

DOI:10.1136/bmj.39105.428981.BE
PMID:17289732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1796666/
Abstract

It is impossible to predict which drugs will be effective against a new pandemic strain of influenza. argue that failure to stockpile both major classes of antiviral drugs could prove costly

摘要

无法预测哪些药物会对新型大流行性流感毒株有效。有人认为，不储备这两类主要的抗病毒药物可能代价高昂。

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本文引用的文献

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WHO Rapid Advice Guidelines for pharmacological management of sporadic human infection with avian influenza A (H5N1) virus.世界卫生组织关于散发性甲型禽流感（H5N1）病毒人间感染的药物治疗快速建议指南。
Lancet Infect Dis. 2007 Jan;7(1):21-31. doi: 10.1016/S1473-3099(06)70684-3.
2
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia.人感染甲型H5N1流感的致死结局与高病毒载量和细胞因子血症有关。
Nat Med. 2006 Oct;12(10):1203-7. doi: 10.1038/nm1477. Epub 2006 Sep 10.
3
Pandemic influenza: a potential role for statins in treatment and prophylaxis.大流行性流感：他汀类药物在治疗和预防中的潜在作用。
Clin Infect Dis. 2006 Jul 15;43(2):199-205. doi: 10.1086/505116. Epub 2006 Jun 12.
4
Distribution of amantadine-resistant H5N1 avian influenza variants in Asia.亚洲地区抗金刚烷胺的H5N1禽流感变异株的分布情况。
J Infect Dis. 2006 Jun 15;193(12):1626-9. doi: 10.1086/504723. Epub 2006 May 9.
5
Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants.联合化疗是一种降低甲型流感耐药变异株出现的潜在策略。
Antiviral Res. 2006 Jul;70(3):121-31. doi: 10.1016/j.antiviral.2006.01.012. Epub 2006 Feb 21.
6
Oseltamivir resistance during treatment of influenza A (H5N1) infection.甲型H5N1流感感染治疗期间的奥司他韦耐药性。
N Engl J Med. 2005 Dec 22;353(25):2667-72. doi: 10.1056/NEJMoa054512.
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Evolution of H5N1 avian influenza viruses in Asia.亚洲H5N1禽流感病毒的演变
Emerg Infect Dis. 2005 Oct;11(10):1515-21. doi: 10.3201/eid1110.050644.
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