Miligi Lucia, Costantini Adele Seniori, Benvenuti Alessandra, Veraldi Angela, Tumino Rosario, Ramazzotti Valerio, Vindigni Carla, Amadori Dino, Fontana Arabella, Rodella Stefania, Stagnaro Emanuele, Crosignani Paolo, Vineis Paolo
Instituto Toscano Tumori-Unit of Environmental and Occupational Epidemiology, Centre for Study and Cancer Prevention, Florence, Italy.
Arch Environ Occup Health. 2005 Sep-Oct;60(5):249-56. doi: 10.3200/AEOH.60.5.249-256.
In the context of a population-based case-control study in Italy, the authors investigated the possible association between the personal use of hair dyes and non-Hodgkin's lymphoma (NHL), leukemia, multiple myeloma, and Hodgkin's disease. They collected all incident cases of hematolymphopoietic malignancies; the control group was formed with a random sample of the general population. Overall, the authors interviewed 2,737 research subjects and 1,779 control subjects. Among women, the authors found no association between ever using hair dyes and the risk of hematolymphopoietic malignancies. However, for permanent hair dyes, the authors observed a slightly increased risk of lymphocytic leukemia (odds ratio [OR] = 1.3; 95% confidence interval [CI] = 0.8-2.2) and of follicular subtypes of NHL (OR= 1.3; 95% CI = 0.8-2.0). Women who used black hair dye colors were at an increased risk of developing leukemia (OR = 1.9; 95% CI = 1.0-3.4), in particular chronic lymphocytic leukemia (OR = 3.0; 95% CI = 1.1-7.5). In spite of the lack of information on the timing and frequency of hair dye use and the imprecision of the ORs, associations were suggested between leukemia and permanent black hair dye use and follicular NHL and the use of permanent hair dyes.
在意大利一项基于人群的病例对照研究中，作者调查了个人使用染发剂与非霍奇金淋巴瘤（NHL）、白血病、多发性骨髓瘤和霍奇金病之间可能存在的关联。他们收集了所有血液淋巴系统恶性肿瘤的新发病例；对照组由从普通人群中随机抽取的样本组成。总体而言，作者采访了2737名研究对象和1779名对照对象。在女性中，作者发现曾经使用染发剂与血液淋巴系统恶性肿瘤风险之间无关联。然而，对于永久性染发剂，作者观察到淋巴细胞白血病（优势比[OR]=1.3；95%置信区间[CI]=0.8 - 2.2）和NHL滤泡亚型（OR = 1.3；95% CI = 0.8 - 2.0）的风险略有增加。使用黑色染发剂的女性患白血病的风险增加（OR = 1.9；95% CI = 1.0 - 3.4），尤其是慢性淋巴细胞白血病（OR = 3.0；95% CI = 1.1 - 7.5）。尽管缺乏关于染发剂使用时间和频率的信息以及优势比的不精确性，但仍提示白血病与永久性黑色染发剂使用以及滤泡性NHL与永久性染发剂使用之间存在关联。
