Johansson Gabriella M, Jönsson Bo A G, Axmon Anna, Lindh Christian H, Lind Marie-Louise, Gustavsson Mats, Broberg Karin, Boman Anders, Meding Birgitta, Lidén Carola, Albin Maria
Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Department of Occupational and Environmental Medicine, University and Regional Laboratories Region Skåne, Lund, Sweden.
Occup Environ Med. 2015 Jan;72(1):57-63. doi: 10.1136/oemed-2013-101960. Epub 2014 Jun 9.
Carcinogenic aromatic amines derived from hair dyes have recently received new attention. One of these is ortho (o)-toluidine, which is classified as carcinogenic to humans.
To clarify exposure of hairdressers to potentially carcinogenic aromatic amines, including o-toluidine.
We measured eight potentially carcinogenic aromatic amines in the blood of 295 hairdressers, 32 users of hair dyes and 60 controls. The study was restricted to female non-smokers. Lifestyle data were collected for all participants using self-administered questionnaires. Blood samples were taken for analysis of ortho-, meta (m)- and para (p)-toluidine; 2-, 3- and 4-ethylaniline, 2,3- and 3,4-dimethylaniline as haemoglobin adducts. The samples were analysed with gas chromatography-tandem mass spectrometry.
Generally, adduct concentrations were in the range of 0-200 pg/g haemoglobin. A comparison of the adduct concentrations found in hairdressers, consumers and controls showed no statistically significant differences. However, for hairdressers, o- and m-toluidine concentrations increased significantly with the weekly number of hair waving (p=0.020) and permanent hair dyeing treatments (p=0.026), respectively. o-Toluidine and m-Toluidine concentrations also tended (p=0.076 and 0.080, respectively) to increase with the frequency of light-colour permanent hair dye treatments.
Hairdressers who use light-colour permanent hair dyes, other permanent hair dyes and hair waving treatments seem to be exposed to o- and m-toluidine as indicated by associations with the number of treatments performed. Analyses of hair waving and hair dye products should be performed to identify the possible sources of exposure to o- and m-toluidine.
源自染发剂的致癌芳香胺最近受到了新的关注。其中之一是邻甲苯胺，它被归类为对人类致癌物质。
明确美发师接触潜在致癌芳香胺（包括邻甲苯胺）的情况。
我们测量了295名美发师、32名染发剂使用者和60名对照者血液中的8种潜在致癌芳香胺。该研究仅限于女性不吸烟者。使用自填问卷收集所有参与者的生活方式数据。采集血样以分析邻、间、对甲苯胺；2-、3-和4-乙基苯胺，2,3-和3,4-二甲基苯胺作为血红蛋白加合物。样品用气相色谱-串联质谱法进行分析。
一般来说，加合物浓度在0 - 200 pg/g血红蛋白范围内。美发师、消费者和对照者中发现的加合物浓度比较显示无统计学显著差异。然而，对于美发师，邻甲苯胺和间甲苯胺浓度分别随每周烫发次数（p = 0.020）和永久性染发治疗次数（p = 0.026）显著增加。邻甲苯胺和间甲苯胺浓度也分别有随浅色永久性染发治疗频率增加的趋势（分别为p = 0.076和0.080）。
使用浅色永久性染发剂、其他永久性染发剂和烫发治疗的美发师似乎接触到邻甲苯胺和间甲苯胺，这通过与所进行治疗次数的关联表明。应分析烫发和染发产品以确定邻甲苯胺和间甲苯胺的可能接触来源。
