Department of Hematology, The First Affiliated Hospital and College of Clinical Medicine, Henan University of Science and Technology, Luoyang, China,
Department of Hematology, The First Affiliated Hospital and College of Clinical Medicine, Henan University of Science and Technology, Luoyang, China.
Med Princ Pract. 2019;28(3):222-230. doi: 10.1159/000496447. Epub 2018 Dec 24.
Epidemiologic studies have suggested hair dye to be a risk factor for many cancers. However, previous studies on the association between the personal use of hair dye and risk of non-Hodgkin's lymphoma (NHL) have been inconclusive.
The PubMed, Embase, Cochrane Library, and Web of Science databases, as well as the references cited in included studies, were searched for relevant studies up to February 10, 2015. Odds ratios (OR) with 95% confidence intervals (CI) were applied to assess the strength of the association. Publication bias was evaluated using a funnel plot by Egger's and Begg's tests.
A total of 16 studies were included in the analysis, including 13 case-control studies and 3 cohort studies. The present meta-analysis results revealed that the risk of NHL in a high population of hair dye users was 14% (OR 1.14, 95% CI 1.01-1.29). Furthermore, individuals who used more than 20 pack-years of hair dye had increased risk of NHL.
The outcomes indicate that hair dye use increases the risk of NHL, especially for females. Hence, people who frequently use hair dyes or have been using hair dyes for more than 20 years should minimize their exposure to hair dye products to prevent the risk of NHL.
流行病学研究表明，染发剂可能是许多癌症的一个风险因素。然而，此前关于个人使用染发剂与非霍奇金淋巴瘤（NHL）风险之间的关联的研究尚无定论。
检索了PubMed、Embase、Cochrane 图书馆和 Web of Science 数据库，以及纳入研究的参考文献，截至 2015 年 2 月 10 日，查找相关研究。应用比值比（OR）和 95%置信区间（CI）来评估关联的强度。通过 Egger 和 Begg 检验的漏斗图评估发表偏倚。
共有 16 项研究纳入分析，包括 13 项病例对照研究和 3 项队列研究。本荟萃分析结果表明，高染发人群患 NHL 的风险增加了 14%（OR 1.14，95% CI 1.01-1.29）。此外，使用超过 20 个染发量年的个体患 NHL 的风险增加。
结果表明，使用染发剂会增加 NHL 的风险，尤其是对女性而言。因此，经常使用染发剂或已经使用染发剂超过 20 年的人应尽量减少接触染发剂产品，以降低 NHL 的风险。
