小鼠乳腺肿瘤病毒变体之间核酸序列的关系。
Relationship in nucleic acid sequences between mouse mammary tumor virus variants.
作者信息
Michalides R, Schlom J
出版信息
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4635-9. doi: 10.1073/pnas.72.11.4635.
Abstract
Primary cultures of mouse mammary carcinomas were used as a source of both radioactively labeled and unlabeled 60-70S RNA of mouse mammary tumor virus (MMTV) obtained from various mouse strains. Competition molecular hybridization experiments revealed that, within the limits of the assay, the RNAs of the MMTVs synthesized in culture by the tumors of the mouse strains RIII, GR, A, and C3H, are identical. A comparison of the genomes of the milk-transmitted MMTV(C3H) and the vertically transmitted MMTV(C3Hf) revealed that these two viruses are approximately 75% similar. No nucleic acid sequence homology was observed between MMTV(C3H) 60-70S RNA and the RNAs of murine leukemia virus, Mason-Pfizer virus, or the BrdUrd-induced type-B quinea pig virus.
摘要
小鼠乳腺癌的原代培养物被用作从各种小鼠品系获得的放射性标记和未标记的小鼠乳腺肿瘤病毒（MMTV）60 - 70S RNA的来源。竞争分子杂交实验表明，在该测定的限度内，由小鼠品系RIII、GR、A和C3H的肿瘤在培养物中合成的MMTV的RNA是相同的。对乳汁传播的MMTV（C3H）和垂直传播的MMTV（C3Hf）的基因组进行比较发现，这两种病毒大约有75%的相似性。在MMTV（C3H）60 - 70S RNA与鼠白血病病毒、梅森 - 辉瑞病毒或BrdUrd诱导的B型豚鼠病毒的RNA之间未观察到核酸序列同源性。
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