Langseth H, Johansen B V, Nesland J M, Kjaerheim K
Cancer Registry of Norway, Institute of Population-based Cancer Research, Montebello, N-0310 Oslo, Norway.
Int J Gynecol Cancer. 2007 Jan-Feb;17(1):44-9. doi: 10.1111/j.1525-1438.2006.00768.x.
An elevated risk of ovarian cancer has been observed in Norwegian pulp and paper workers who were possibly occupationally exposed to asbestos. The present study was initiated to investigate if the increased risk could be associated with asbestos fibers in ovarian tissue from workers in this industry. Normal ovarian tissue specimens from three groups of women were included in the study. The case group included specimens from 46 women diagnosed with ovarian cancer in the period 1953-2000, and who had been working in one or more pulp and paper mills between 1920 and 1993. Normal ovarian tissue specimens from two control groups without occupational history from pulp and paper work were selected from the Cancer Registry database. Tissue blocks were digested and prepared for transmission electron microscopy. Number of fibers per gram wet weight was calculated. Asbestos fibers were found in normal ovarian tissue from two subjects in the case group, while no fibers were found in the control groups. The two asbestos positive cases had been working as paper sorter/packer and chlorine plant worker, respectively. Both were possibly secondary exposed to asbestos from family members working as insulators. We conclude that the findings in this study did not allow drawing any firm conclusion about an association between occupational exposure to asbestos and ovarian cancer in Norwegian pulp and paper workers. Our study confirms that asbestos fibers may reach the ovaries and demonstrates that the applied method is appropriate for identification of the fibers.
在挪威可能职业性接触石棉的纸浆和造纸工人中，已观察到卵巢癌风险升高。本研究旨在调查这种风险增加是否可能与该行业工人卵巢组织中的石棉纤维有关。研究纳入了三组女性的正常卵巢组织标本。病例组包括1953年至2000年期间被诊断患有卵巢癌、且在1920年至1993年期间曾在一个或多个纸浆和造纸厂工作的46名女性的标本。从癌症登记数据库中选取了两个无纸浆和造纸工作职业史的对照组的正常卵巢组织标本。将组织块进行消化并制备用于透射电子显微镜检查。计算每克湿重的纤维数量。病例组中有两名受试者的正常卵巢组织中发现了石棉纤维，而对照组中未发现纤维。这两名石棉阳性病例分别曾担任纸张分拣员/包装工和氯厂工人。两人可能都是通过从事绝缘工作的家庭成员而间接接触石棉。我们得出结论，本研究结果无法就挪威纸浆和造纸工人职业性接触石棉与卵巢癌之间的关联得出任何确凿结论。我们的研究证实石棉纤维可能会到达卵巢，并表明所应用的方法适用于纤维的识别。
