疟原虫感染红细胞的电生理学研究：现状
Electrophysiological studies of malaria parasite-infected erythrocytes: current status.
作者信息
Staines Henry M, Alkhalil Abdulnaser, Allen Richard J, De Jonge Hugo R, Derbyshire Elvira, Egée Stéphane, Ginsburg Hagai, Hill David A, Huber Stephan M, Kirk Kiaran, Lang Florian, Lisk Godfrey, Oteng Eugene, Pillai Ajay D, Rayavara Kempaiah, Rouhani Sherin, Saliba Kevin J, Shen Crystal, Solomon Tsione, Thomas Serge L Y, Verloo Patrick, Desai Sanjay A
机构信息
Centre for Infection, Division of Cellular and Molecular Medicine, St. George's, University of London, London SW17 0RE, UK.
出版信息
Int J Parasitol. 2007 Apr;37(5):475-82. doi: 10.1016/j.ijpara.2006.12.013. Epub 2007 Jan 9.
The altered permeability characteristics of erythrocytes infected with malaria parasites have been a source of interest for over 30 years. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. However, conflicting results and differing interpretations of the data have led to confusion in this field. In an effort to unravel these issues, the groups involved recently came together for a week of discussion and experimentation. In this article, the various models for altered transport are reviewed, together with the areas of consensus in the field and those that require a better understanding.
30多年来，感染疟原虫的红细胞通透性特征的改变一直是人们感兴趣的一个问题。最近的电生理学研究提供了有力证据，表明这些变化反映了宿主红细胞质膜中离子通道的跨膜运输。然而，相互矛盾的结果和对数据的不同解释导致了该领域的混乱。为了厘清这些问题，相关团队最近齐聚一堂，进行了为期一周的讨论和实验。在本文中，我们回顾了各种运输改变的模型，以及该领域的共识领域和那些需要更好理解的领域。
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