Fujii H, Cunha G R, Norman J T
J Urol. 1982 Oct;128(4):858-61. doi: 10.1016/s0022-5347(17)53221-8.
Epithelial cells of non-glandular, transitional cell carcinomas from rat urinary bladders were associated with embryonic rat urogenital sinus mesenchyme (a prostatic inductor) and transplanted into syngeneic adult male hosts. Neoplastic bladder epithelium formed glandular (adenocarcinomatous) acini in a substantial number of recombinants, suggesting that the mesenchyme (stroma) may influence the histotypic organization of carcinoma cells and induce the neoplastic epithelium to express a novel phenotype.
来自大鼠膀胱的非腺性移行细胞癌的上皮细胞与胚胎大鼠泌尿生殖窦间充质（一种前列腺诱导物）相结合，并移植到同基因成年雄性宿主中。在大量重组体中，肿瘤性膀胱上皮形成了腺泡（腺癌性），这表明间充质（基质）可能影响癌细胞的组织型结构，并诱导肿瘤上皮表达一种新的表型。
