Macho L, Alexandrová M, Hromadová M, Strbák V, Kvetnanský R
Physiol Bohemoslov. 1975;24(6):501-8.
Undernutrition and overnutrition during the suckling period -- achieved by adjusting the number of infant rats per litter to 4, 8 and 14 -- resulted in a decrease in the plasma corticosterone level and in corticosterone production by the adrenals in vitro in overfed animals at the age of 30, 180 and 300--360 days. An enhanced response to ether anaesthesia or immobilization stress was found in overfed animals from the smallest litters. The results show that a change in postnatal nutrition and in social relationships in the litter influences maturation of the hypoathalamo-hypophysio-adrenal regulatory system; in adulthood this is manifested in changes in production of the adrenal hormones and in the reaction of the adrenals to stress.
哺乳期的营养不足和营养过剩——通过将每窝幼鼠数量调整为4只、8只和14只来实现——导致30日龄、180日龄以及300 - 360日龄的过度喂养动物血浆皮质酮水平降低，且肾上腺体外皮质酮分泌减少。在最小窝的过度喂养动物中发现了对乙醚麻醉或固定应激的反应增强。结果表明，出生后营养和窝内社会关系的变化会影响下丘脑 - 垂体 - 肾上腺调节系统的成熟；成年后，这表现为肾上腺激素分泌的变化以及肾上腺对应激的反应。
