Krinke G, Zák F, Lukás B, Wiesendanger W, Schmidt-Ruppin K H
Arch Virol. 1975;49(1):13-24. doi: 10.1007/BF02175591.
Gross and microscopial morphological changes developing in female guinea-pigs after vaginal infection with HVH 2/Angelotti were studied. In the mucosa of the external genital tract there were inflammatory changes with formation of intra-epithelial vesicles, erosions and ulcerations. In the late stages of the infection signs of inflammatory dysplasia were also observed. The infection spread into the nervous system and produced characteristic inflammatory changes. The inflammation began as a bilateral posterior myelitis and ascended in the course of infection through the upper spinal-cord towards the brain-stem. The morphological changes were preceded by increased virus replication in the respective tissues and were correlated in time with clinical symptoms. The morphological changes seen at the site of inoculation in the external genital tract of the guinea-pig bore a certain resemblance to those seen in some cases of human infection with the same type of virus.
研究了雌性豚鼠经阴道感染H VH 2/安杰洛蒂病毒后所发生的大体和微观形态学变化。在外阴生殖道黏膜中出现了炎症变化，形成了上皮内水疱、糜烂和溃疡。在感染后期还观察到了炎症发育异常的迹象。感染扩散至神经系统并产生了特征性炎症变化。炎症始于双侧后脊髓炎，并在感染过程中通过上脊髓向上蔓延至脑干。形态学变化之前，相应组织中的病毒复制增加，且在时间上与临床症状相关。在豚鼠外生殖器接种部位所见的形态学变化与人类感染同型病毒的某些病例中所见的变化有一定相似之处。
