Stanberry L R, Kern E R, Richards J T, Abbott T M, Overall J C
J Infect Dis. 1982 Sep;146(3):397-404. doi: 10.1093/infdis/146.3.397.
Guinea pigs inoculated intravaginally with herpes simplex virus type 2 (HSV-2) developed a self-limiting infection characterized by vesiculo-ulcerative lesions on the external genital skin, urinary retention, and hindlimb paralysis. Infection rarely resulted in death. Virologic, histologic, and immunoperoxidase data suggested the following scheme for viral pathogenesis: initial replication in the introitus, vagina, and bladder; spread via sensory nerves to the lumbosacral dorsal root ganglia and spinal cord, and transmission via peripheral nerves to the external genital skin to produce the characteristic lesions. After recovery from primary infection, animals developed recurrent vesicular lesions, shed virus from genital sites in the absence of lesions, and harbored latent HSV-2 in dorsal root ganglia. Genital infection in the guinea pig shares many features with genital herpes in humans and provides a model to explore mechanisms of latency and reactivation and to evaluate several methods for control of recurrent disease.
经阴道接种2型单纯疱疹病毒（HSV-2）的豚鼠发生了一种自限性感染，其特征为外生殖器皮肤出现水疱性溃疡病变、尿潴留和后肢麻痹。感染很少导致死亡。病毒学、组织学和免疫过氧化物酶数据提示了以下病毒发病机制：最初在阴道口、阴道和膀胱复制；通过感觉神经扩散至腰骶部背根神经节和脊髓，并通过外周神经传播至外生殖器皮肤以产生特征性病变。初次感染恢复后，动物出现复发性水疱病变，在无病变时从生殖器部位排出病毒，并在背根神经节中潜伏HSV-2。豚鼠的生殖器感染与人类生殖器疱疹有许多共同特征，为探索潜伏和再激活机制以及评估控制复发性疾病的几种方法提供了一个模型。
