Celleno Leonardo, Tolaini Maria Vittoria, D'Amore Alessandra, Perricone Nicholas V, Preuss Harry G
Cosmetic Research Center, dell'Università Cattolica di Roma, Rome, Italy.
Int J Med Sci. 2007 Jan 24;4(1):45-52. doi: 10.7150/ijms.4.45.
More than one billion human adults worldwide are overweight and, therefore, are at higher risk of developing cardiovascular diseases, diabetes, and a variety of other chronic perturbations. Many believe that use of natural dietary supplements could aid in the struggle against obesity. So-called "starch blockers" are listed among natural weight loss supplements. Theoretically, they may promote weight loss by interfering with the breakdown of complex carbohydrates thereby reducing, or at least slowing, the digestive availability of carbohydrate-derived calories and/or by providing resistant starches to the lower gastrointestinal tract.
The present research study examines a dietary supplement containing 445 mg of Phaseolus vulgaris extract derived from the white kidney bean, previously shown to inhibit the activity of the digestive enzyme alpha amylase, on body composition of overweight human subjects.
A randomized, double-blinded, placebo-controlled study was conducted on 60 pre-selected, slightly overweight volunteers, whose weight had been essentially stable for at least six months. The volunteers were divided into two groups, homogeneous for age, gender, and body weight. The test product containing Phaseolus vulgaris extract and the placebo were taken one tablet per day for 30 consecutive days before a main meal rich in carbohydrates. Each subject's body weight, fat and non-fat mass, skin fold thickness, and waist/hip/thigh circumferences were measured.
After 30 days, subjects receiving Phaseolus vulgaris extract with a carbohydrate-rich, 2000- to 2200-calorie diet had significantly (p<0.001) greater reduction of body weight, BMI, fat mass, adipose tissue thickness, and waist,/hip/ thigh circumferences while maintaining lean body mass compared to subjects receiving placebo.
The results indicate that Phaseolus vulgaris extract produces significant decrements in body weight and suggest decrements in fat mass in the face of maintained lean body mass.
全球超过10亿成年人超重，因此患心血管疾病、糖尿病和各种其他慢性疾病的风险更高。许多人认为使用天然膳食补充剂有助于对抗肥胖。所谓的“淀粉阻滞剂”被列为天然减肥补充剂。从理论上讲，它们可能通过干扰复合碳水化合物的分解来促进体重减轻，从而减少或至少减缓碳水化合物衍生热量的消化利用率，和/或通过向下消化道提供抗性淀粉来实现。
本研究调查了一种含有445毫克白芸豆提取物的膳食补充剂对超重人体受试者身体成分的影响，该提取物先前已被证明能抑制消化酶α淀粉酶的活性。
对60名预先选定的轻度超重志愿者进行了一项随机、双盲、安慰剂对照研究，他们的体重在至少六个月内基本稳定。志愿者按年龄、性别和体重分为两组。在富含碳水化合物的主餐前，连续30天每天服用一片含有白芸豆提取物的测试产品和安慰剂。测量了每个受试者的体重、脂肪和非脂肪质量、皮褶厚度以及腰围/臀围/大腿围。
30天后，与接受安慰剂的受试者相比，接受白芸豆提取物并摄入富含碳水化合物的2000至2200卡路里饮食的受试者，在保持瘦体重的同时，体重、BMI、脂肪量、脂肪组织厚度以及腰围/臀围/大腿围显著降低（p<0.001）。
结果表明，白芸豆提取物能显著降低体重，并在保持瘦体重的情况下减少脂肪量。
