Baker Dean Adam, Beckingham Kathleen Mary, Armstrong James Douglas
School of Informatics, University of Edinburgh, Edinburgh, UK.
J Comp Neurol. 2007 Apr 10;501(5):756-64. doi: 10.1002/cne.21257.
In animals, sensing gravity is supported by mechanosensory neurons that send information to the central brain for integration along with other modalities. In Drosophila, candidate sensory organs for detecting the gravity vector were predicted from the results of a recent forward genetic screen. This analysis also suggested possible roles for the central complex and antennal system in Drosophila. Using the same vertical maze assay employed in the original screen, we investigated the roles of these candidate neural structures by spatial and temporal inactivation of synaptic transmission with the GAL4/UAS-shibire[ts1] system. We correlate changes in the maze behavior of flies with specific inhibition of synaptic transmission for key brain neuropil that includes the central complex and antenno-glomerular tract. Further, our results point toward a minimal, or nonexistent, role for the mushroom bodies.
在动物中，重力感知由机械感觉神经元支持，这些神经元将信息发送到中枢大脑，以便与其他感觉方式进行整合。在果蝇中，根据最近的正向遗传筛选结果预测了检测重力矢量的候选感觉器官。该分析还暗示了果蝇中枢复合体和触角系统的可能作用。使用原始筛选中使用的相同垂直迷宫试验，我们通过GAL4/UAS-shibire[ts1]系统对突触传递进行空间和时间失活，研究了这些候选神经结构的作用。我们将果蝇迷宫行为的变化与包括中枢复合体和触角-肾小球束在内的关键脑髓质突触传递的特异性抑制相关联。此外，我们的结果表明蘑菇体的作用极小或不存在。
