Gazerani Parisa, Pourpak Zahra, Ahmadiani A, Hemmati A, Kazemnejad A
Department of Neuroscience Research Center, Shaheed Beheshri University of Medical Sciences, Tehran, Iran.
Iran J Allergy Asthma Immunol. 2003 Mar;2(1):17-24.
Although migraine affects about 15 % of the population, and many studies have been performed to find the mechanism and successful management, the physiopathology of migraine is still largely unknown. The possibility of an IgE-mediated allergic mechanism and the role of histamine remains controversial. The aim of the present study was the evaluation of serum total IgE and histamine levels in migraine patients and the intluence of allergy on them. 70 patients (18-58 years) with migraine without aura were divided in to 2 groups according to their history of allergy (60% with and 40% without allergy). Serum samples were collected during fasting without allowing any premedication in 2 conditions of attack and remission periods. There was a control group containing 45 healthy volunteers. Serum total IgE and histamine levels were measured by ELISA and fluorimetric methods respectively. Mean and standard error of serum histamine (ng/ml) and total IgE (lU/mI) levels were found in control group as 48.16+/-2.70, 38.31+/-3.20 and in migraine with an allergy group as 159.11+/-4.60, 303.30+/-42.50 and in migraine without an allergy group as 105.01 +/-8.50, 79.07+/-2.70 respectively. Total IgE levels in migraine group with allergy were found significantly (P<0.0001) above the control and another group suggesting an influence of an IgE-mediated mechanism on migraine. Plasma histamine levels were significantly elevated (P<0.0001) in patients with migraine both during headache and symptom-free periods compared with control group although it shows that there is an increased susceptibility to histamine in allergic conditions, nonetheless this molecule has also an unrelated role in migraine. The relationship between allergy and migraine can be based in part on IgE-mediated mechanism, with histamine release playing an important role. Thus avoidance of allergic conditions in migraine patients may be a simple helpful way to prophylaxis or their treatment.
尽管偏头痛影响着约15%的人口，并且已经进行了许多研究来探寻其发病机制和有效治疗方法，但偏头痛的生理病理学在很大程度上仍然未知。免疫球蛋白E（IgE）介导的过敏机制的可能性以及组胺的作用仍存在争议。本研究的目的是评估偏头痛患者的血清总IgE和组胺水平，以及过敏对它们的影响。70例（年龄在18 - 58岁之间）无先兆偏头痛患者根据过敏史分为两组（60%有过敏史，40%无过敏史）。在发作期和缓解期这两种情况下，于禁食状态下采集血清样本，且不允许进行任何预处理。有一个包含45名健康志愿者的对照组。血清总IgE和组胺水平分别通过酶联免疫吸附测定（ELISA）法和荧光测定法进行检测。对照组血清组胺（纳克/毫升）和总IgE（国际单位/毫升）水平的均值及标准误分别为48.16±2.70、38.31±3.20，有过敏史的偏头痛组分别为159.11±4.60、303.30±42.50，无过敏史的偏头痛组分别为105.01±8.50、79.07±2.70。有过敏史的偏头痛组的总IgE水平显著高于对照组和另一组（P<0.0001），提示IgE介导的机制对偏头痛有影响。与对照组相比，偏头痛患者在头痛期和无症状期的血浆组胺水平均显著升高（P<0.0001），尽管这表明在过敏状态下对组胺的易感性增加，但该分子在偏头痛中也有独立作用。过敏与偏头痛之间的关系可能部分基于IgE介导的机制，组胺释放起重要作用。因此，避免偏头痛患者接触过敏情况可能是一种简单有效的预防或治疗方法。
