Sharifi Zohreh, Emadi Ghanjin Sekyneh
Research Center of Iranian Blood Transfusion Organization (IBTO), Tehran, Iran.
Iran J Allergy Asthma Immunol. 2005 Jun;4(2):95-8.
Varicella zoster virus (VZV), the causative agent of chicken pox and shingles, can cause severe systemic infections of the CNS and the respiratory tract in immunocompetent individuals as well as in immunocompromized patients.The aim of this cross-sectional study was to assess the prevalence of antibody Varicella zoster virus in different age groups.The enzyme linked immunosorbent assay (ELISA) method was used to assess the presence of anti -VZV antibody.A total of 635 serum samples were collected. Age specific prevalence of IgG antibody to VZV showed a progressive increase with age in both males and females. The overall seroprevalence rate was 83.6%. Prevalence of antibodies was 59.7% in the age group of less than 10 years, 60.4 % in 10-14 years, 87.5 % in 15-19 years, 88 % in 20-24 years, 89.4 % in 25-29 years and 87.9 % in 30-39 years.The data show that children should be considered as a target group for prevention programs against VZV infection.
水痘带状疱疹病毒（VZV）是水痘和带状疱疹的病原体，在免疫功能正常的个体以及免疫功能低下的患者中，均可引起中枢神经系统和呼吸道的严重全身性感染。本横断面研究的目的是评估不同年龄组中水痘带状疱疹病毒抗体的流行情况。采用酶联免疫吸附测定（ELISA）法评估抗VZV抗体的存在情况。共收集了635份血清样本。VZV IgG抗体的年龄特异性流行率在男性和女性中均随年龄增长而逐渐升高。总体血清阳性率为83.6%。抗体流行率在小于10岁年龄组为59.7%，10 - 14岁为60.4%，15 - 19岁为87.5%，20 - 24岁为88%，25 - 29岁为89.4%，30 - 39岁为87.9%。数据表明，儿童应被视为预防VZV感染项目的目标群体。
