Ruge S, Sørensen S, Vejtorp M, Vejerslev L O
Department of Obstetrics and Gynaecology, Hvidovre University Hospital, Copenhagen, Denmark.
Fertil Steril. 1992 Jan;57(1):102-6. doi: 10.1016/s0015-0282(16)54784-0.
To determine the serum level of the secretory endometrial protein, placental protein 14 (PP14) and progesterone (P) in women with ectopic gestation.
Blood samples were collected prospectively and preoperatively. Reference range was determined from a prospective population of 98 women with uncomplicated pregnancies and normal outcome.
The women were admitted to a university hospital.
Fifty-nine women with laparoscopically verified ectopic pregnancy entered the study.
At the time of diagnosis PP14 and P were measured.
After observing the low serum levels of PP14 and P, a correlation analysis was made and compared with the findings in normally pregnant women.
A significant positive correlation was found between the level of PP14 and P (P less than 0.00002), not found in normal intrauterine pregnancies.
These findings suggest that the regulation of the PP14 production involves either a control mechanism from the ovary or is mediated by paracrine secretion.
测定异位妊娠女性血清中分泌型子宫内膜蛋白、胎盘蛋白14（PP14）和孕酮（P）的水平。
前瞻性地在术前采集血样。参考范围来自98例妊娠情况正常且结局良好的女性组成的前瞻性人群。
这些女性被收入一所大学医院。
59例经腹腔镜证实为异位妊娠的女性进入研究。
在诊断时测定PP14和P。
观察到PP14和P的血清水平较低后，进行相关性分析，并与正常妊娠女性的结果进行比较。
发现PP14水平与P水平之间存在显著正相关（P<0.00002），而正常宫内妊娠中未发现这种相关性。
这些发现表明，PP14产生的调节涉及来自卵巢的控制机制或由旁分泌介导。
