Stabile I, Olajide F, Chard T, Grudzinskas J G
Joint Academic Unit of Obstetrics, Gynaecology and Reproductive Physiology, Royal London Hospital, UK.
Br J Obstet Gynaecol. 1994 Sep;101(9):762-4. doi: 10.1111/j.1471-0528.1994.tb11942.x.
To determine circulating levels of placental protein 14 (PP14) in complications of early pregnancy.
Biochemical monitoring of women presenting with vaginal bleeding and/or abdominal pain.
An emergency gynaecological ultrasound clinic in a London teaching hospital.
Venous blood samples were obtained from 67 women with normal pregnancy (n = 9), ectopic pregnancy (n = 26) and failed intrauterine pregnancy (n = 32). This group included anembryonic pregnancy (n = 18), missed miscarriage (n = 2), spontaneous miscarriage of a previously demonstrated live fetus (n = 6), incomplete miscarriage (n = 4), complete miscarriage (n = 1) and molar pregnancy (n = 1).
Serum PP14 levels in the group of women with a failed intrauterine pregnancy in relation to the normal range for PP14.
Eighty-one percent of women who miscarried spontaneously had normal serum PP14 levels; 81% of women with ectopic pregnancy had depressed (< 5th centile) serum PP14 levels.
Measurements of PP14 may be useful in distinguishing spontaneous miscarriage from ectopic pregnancy, but not in the management of threatened miscarriage.
测定妊娠早期并发症中胎盘蛋白14（PP14）的循环水平。
对出现阴道出血和/或腹痛的女性进行生化监测。
伦敦一家教学医院的妇科急诊超声诊所。
从67名女性中采集静脉血样本，其中包括正常妊娠者（n = 9）、异位妊娠者（n = 26）和宫内妊娠失败患者（n = 32）。该组包括胚胎停育（n = 18）、稽留流产（n = 2）、既往有活胎的自然流产（n = 6）、不全流产（n = 4）、完全流产（n = 1）和葡萄胎（n = 1）。
宫内妊娠失败女性组的血清PP14水平与PP14正常范围的关系。
81%自然流产的女性血清PP14水平正常；81%异位妊娠女性的血清PP14水平降低（<第5百分位数）。
PP14的测定可能有助于鉴别自然流产与异位妊娠，但对先兆流产的处理无帮助。
