Bollschweiler E, Knoppe K, Wolfgarten E, Hölscher A H
Klinik und Poliklinik für Viszeral- und Gefässchirurgie, Universität zu Köln, Kerpener Strasse 62, 50931 Köln.
Z Gastroenterol. 2007 Feb;45(2):177-81. doi: 10.1055/s-2006-927402.
Excessive gastro-esophageal reflux impairs quality of life and predisposes the development of Barrett's mucosa, a precursor to adenocarcinoma of the esophagus. At present, the prevalence of reflux symptoms in the general population has not been well enough established.
In a population-based study, five hundred residents of Cologne between the ages of 20 and 90 years (232 or 46 % males and 268 or 54 % females) were randomly selected from the city register and sent a questionnaire with reflux-related questions. 268 replies (54 %) were accepted into the study. Of these, 45 % were men with a median age of 58 years. The median female age was 54 years.
34 % of the respondents (n = 92) admitted having heartburn symptoms. There was no significant difference based on gender. There was little variation in heartburn frequency between individual age groups: only respondents in their forties and those in their sixties had more frequent symptoms (in 45 % of respondents). Heartburn incidence was more common in men between 40 - 50 and in women between 60 - 70 years of age. Twenty-three (25 %) of the 92 respondents with heartburn admitted to reflux symptoms more than twice per week. 45 % of these "refluxers" took medications for their heartburn. 43 % of the refluxers visited a doctor concerning their symptoms, and 72 % of these underwent endoscopy.
Approximately one third of the Cologne adult population suffers gastro-esophageal reflux. Close to ten percent of the population have multiple episodes of symptoms per week. The presence of symptoms occurs indiscriminately in men and women and varies only marginally according to age.
过度的胃食管反流会损害生活质量，并易引发巴雷特黏膜，这是食管腺癌的癌前病变。目前，普通人群中反流症状的患病率尚未得到充分确定。
在一项基于人群的研究中，从科隆市的户籍登记中随机选取了500名年龄在20至90岁之间的居民（232名或46%为男性，268名或54%为女性），并向他们发送了一份包含反流相关问题的问卷。268份回复（54%）被纳入研究。其中，45%为男性，中位年龄为58岁。女性中位年龄为54岁。
34%的受访者（n = 92）承认有烧心症状。基于性别无显著差异。各年龄组之间烧心频率变化不大：只有四十多岁和六十多岁的受访者症状更频繁（45%的受访者）。烧心发生率在40 - 50岁的男性和60 - 70岁的女性中更为常见。92名有烧心症状的受访者中有23名（25%）承认每周反流症状超过两次。这些“反流者”中有45%服用治疗烧心的药物。43%的反流者因症状去看医生，其中72%接受了内窥镜检查。
科隆成年人口中约三分之一患有胃食管反流。近10%的人口每周有多次症状发作。症状在男性和女性中无差别出现，仅随年龄有轻微变化。
