Nilsson M, Johnsen R, Ye W, Hveem K, Lagergren J
Department of Surgery, Karolinska Institrutet, Karolinska Hospital, SE-171 76 Stockholm, Sweden.
Scand J Gastroenterol. 2004 Nov;39(11):1040-5. doi: 10.1080/00365520410003498.
Most previous studies of reflux symptom prevalence are of small sample size. No reliable data concerning age- and sex-stratified prevalence are available.
Among 65,363 adult participants in a public health survey in Nord-Trondelag, Norway, 58,596 (90%) responded concerning occurrence and severity of heartburn or regurgitation during the past 12 months. The prevalence of minor, severe and any reflux symptoms was calculated, including stratification for age and sex. In order to examine whether the relative risk of reflux symptoms between sexes, in different age groups, was affected by other potential risk factors for reflux, confounding effects were tested using multivariate logistic regression. Odds ratios and their 95% confidence intervals were used to estimate relative risks.
Total prevalence of reflux symptoms was 31.4%, whereof 26.0% were minor symptoms and 5.4% severe symptoms. The prevalence of symptoms occurring at least weekly was 11.6%. Among women, the prevalence increased gradually from 22.1% in the youngest age category to 37.5% in the oldest, while among men it gradually increased from 25.8% in the youngest age group to peak at 36.0% between the ages of 50 and 60 years, after which it declined to 33.8% after age 70. A higher prevalence among women compared to men in the oldest age groups was not explained by confounding by body mass, tobacco smoking, alcohol consumption, dietary factors, or physical exercise.
About every third adult person suffered from reflux symptoms. The prevalence increases linearly with age among women, while among men it peaked between the age of 50 and 70 years and thereafter declined.
以往大多数关于反流症状患病率的研究样本量较小。目前尚无关于年龄和性别分层患病率的可靠数据。
在挪威北特伦德拉格郡的一项公共卫生调查中，65363名成年参与者中有58596人（90%）回答了过去12个月内心burn或反流的发生情况及严重程度。计算了轻度、重度及任何反流症状的患病率，包括年龄和性别分层。为了研究不同年龄组中性别之间反流症状的相对风险是否受到其他潜在反流风险因素的影响，使用多因素logistic回归检验混杂效应。比值比及其95%置信区间用于估计相对风险。
反流症状的总患病率为31.4%，其中轻度症状为26.0%，重度症状为5.4%。至少每周出现症状的患病率为11.6%。在女性中，患病率从最年轻年龄组的22.1%逐渐增加到最年长年龄组的37.5%，而在男性中，患病率从最年轻年龄组的25.8%逐渐增加，在50至60岁之间达到峰值36.0%，70岁以后降至33.8%。在最年长年龄组中，女性患病率高于男性这一情况不能用体重、吸烟、饮酒、饮食因素或体育锻炼等混杂因素来解释。
大约每三个成年人中就有一人患有反流症状。女性患病率随年龄呈线性增加，而男性患病率在50至70岁之间达到峰值，此后下降。
