Lopez Ramon, Farber Mark O, Wong Vincent, Lacey Steven E
Indiana University, Fairbanks School of Public Health, Department of Environmental Health Science (Drs Lopez, Lacey); Indiana University Health, Pulmonology-Critical Care (Dr Farber); and Indiana University, Krannert Institute of Cardiology, Department of Medicine, Indianapolis (Dr Wong).
J Occup Environ Med. 2016 Sep;58(9):940-5. doi: 10.1097/JOM.0000000000000832.
We conducted an exposure chamber study in humans using a simulated clinical procedure lasing porcine tissue to demonstrate evidence of effects of exposure to laser-generated particulate matter (LGPM).
We measured pre- and post-exposure changes in exhaled nitric oxide (eNO), spirometry, heart rate variability (HRV), and blood markers of inflammation in five volunteers.
Change in pre- and post-exposure measurements of eNO and spirometry was unremarkable. Neutrophil and lymphocyte counts increased and fibrinogen levels decreased in four of the five subjects. Measures of HRV showed decreases in the standard deviation of normal between beat intervals and sequential 5-minute intervals.
These data represent the first evidence of human physiologic response to LGPM exposure. Further exploration of coagulation effects and HRV is warranted.
我们在人体中进行了一项暴露舱研究，采用模拟临床程序对猪组织进行激光照射，以证明接触激光产生的颗粒物（LGPM）的影响证据。
我们测量了五名志愿者暴露前后呼出一氧化氮（eNO）、肺功能、心率变异性（HRV）以及炎症血液标志物的变化。
暴露前后eNO和肺功能测量值的变化不显著。五名受试者中有四名的中性粒细胞和淋巴细胞计数增加，纤维蛋白原水平降低。HRV测量显示，正常心跳间隔和连续5分钟间隔的标准差降低。
这些数据是人类对LGPM暴露生理反应的首个证据。有必要进一步探索凝血效应和HRV。
