Stein L, Belluzzi J D, Wise C D
Am J Psychiatry. 1977 Jun;134(6):665-9. doi: 10.1176/ajp.134.6.665.
The therapeutic effects of benzodiazepines in psychoneurosis may depend in part on their ability to release or disinhibit a patient's anxiety-suppressed gratification-seeking behavior. Benzodiazepines may disinhibit behavior by reducing the activity of serotonin (and possibly acetylcholine) neurons in the brain's "punishment" system. Reduction of serotonin transmission may be due to a facilitation of gamma-aminobutyric acid (GABA)-mediated presynaptic inhibition at the serotonin nerve terminal.
苯二氮䓬类药物在精神神经症中的治疗效果可能部分取决于它们释放或解除抑制患者焦虑抑制的寻求满足行为的能力。苯二氮䓬类药物可能通过降低大脑“惩罚”系统中血清素（可能还有乙酰胆碱）神经元的活性来解除行为抑制。血清素传递的减少可能是由于在血清素神经末梢促进了γ-氨基丁酸（GABA）介导的突触前抑制。
